Search

Your search keyword '"Parrillo, C"' showing total 2 results
Start Over Author "Parrillo, C" Journal farmaco (societa chimica italiana : 1989)
2 results on '"Parrillo, C"'

1. N-substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo [2.2.2]-octan-6-ones with platelet antiaggregating and local anesthetic activities

Author

Schenone, S., Bruno, O., Ranise, A., Bondavalli, F., michele d'amico, Parrillo, C., Lampa, E., Rossi, F., Schenone, S, Bruno, O, Ranise, A, Bondavalli, F, D'Amico, Michele, Parrillo, C, Lampa, E, and Rossi, Francesco

Subjects
Male, Analgesics, Bridged Bicyclo Compounds, Mice, Oximes, Animals, Humans, Anesthetics, Local, In Vitro Techniques, Anti-Arrhythmia Agents, Antihypertensive Agents, Platelet Aggregation Inhibitors, Rats
Abstract

The synthesis of a series of N-substituted O-(3-amino-2-hydroxypropyl)oximes of 1,3,3-trimethyl-5-endo-(1-piperidinyl or 4-morpholinyl)-2-oxabicyclo [2.2.2]octan-6-ones is described. Some of these ethers showed strong local anesthetic activity in mice and platelet antiaggregating activity in vitro comparable to that of acetylsalicylic acid, as well as moderate hypotensive, antiarrhythmic and analgesic activities in rats and mice.

Published
1992

2. 4-substituted 1-methyl-1H-indazoles with analgesic, antiinflammatory and antipyretic activities

Author

Mosti, L., Menozzi, G., Fossa, P., Schenone, P., Lampa, E., Parrillo, C., michele d'amico, Rossi, F., Mosti, L, Menozzi, G, Fossa, P, Schenone, P, Lampa, E, Parrillo, C, D'Amico, Michele, and Rossi, Francesco

Subjects
Mice, Indazoles, 4-Substituted 1-methyl-1H-indazoles, Anti-Inflammatory Agents, Non-Steroidal, Animals, Humans, Blood Pressure, In Vitro Techniques, Antihypertensive Agents, Platelet Aggregation Inhibitors, Rats
Abstract

The synthesis of [(1-methyl-1H-indazol-4-yl)oxy]acetic acid 4, 1-methyl-1H-indazole-4-acetic acid 9, 2-(1-methyl-1H-indazol-4-yl)propanoic acid 15 and [[(1,5,6,7-tetrahydro-1-methyl-4H-indazol-4-ylidene)amino]oxy]acet ic acid 16, as well as of amides and esters derived from 4 and 9, starting from 1,5,6,7-tetrahydro-1-methyl-4H-indazol-4-one is described. Some of the above compounds showed weak antiinflammatory, analgesic, antipyretic and hypotensive activities in rats and mice, as well as moderate platelet antiaggregating effects in vitro.

Published
1992

Catalog

Books, media, physical & digital resources
See catalog results