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1. [Structure-activity relationship in reactivators of acetylcholinesterase inhibited by phosphoric esters. XII. Hydroxyiminomethylalkylpyridine iodomethylate].

Author

Arena F, Luraschi E, Grifantini M, Manna F, and Parente G

Subjects
Animals, Drug Evaluation, Preclinical, Eels, Enzyme Reactivators pharmacology, Enzyme Reactivators therapeutic use, Mice, Oximes pharmacology, Oximes therapeutic use, Pyridinium Compounds pharmacology, Pyridinium Compounds therapeutic use, Structure-Activity Relationship, Acetylcholinesterase biosynthesis, Cholinesterase Inhibitors poisoning, Enzyme Reactivators chemical synthesis, Organophosphate Poisoning, Oximes chemical synthesis, Pyridinium Compounds chemical synthesis
Abstract

2-Hydroxyiminomethyl-4-alkylpyridine methiodides were prepared and tested for their in vitro reactivating potency on phosphorylated electric eel cholinesterase. They were also tested as in vivo protecting agents: only one of the compounds, 4-methyl-2-hydroxyiminopyridine, offered a greater protection from DFP than 2-PAM, the others had little to no effect.

Published
1978

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