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The endoplasmic reticulum (ER) is the largest membrane system in eukaryotic cells and is the primary site for the biosynthesis of lipids and carbohydrates, as well as for the folding, assembly, modification, and transport of secreted and integrated membrane proteins. The ER membrane complex (EMC) on the ER membrane is an ER multiprotein complex that affects the quality control of membrane proteins, which is abundant and widely preserved. Its disruption has been found to affect a wide range of processes, including protein and lipid synthesis, organelle communication, endoplasmic reticulum stress, and viral maturation, and may lead to neurodevelopmental disorders and cancer. Therefore, EMC has attracted the attention of many scholars and become a hot field. In this paper, we summarized the main contributions of the research of EMC in the past nearly 15 years, and reviewed the structure and function of EMC as well as its related diseases. We hope this review will promote further progress of research on EMC. [ABSTRACT FROM AUTHOR]

Retraction: Chen J, Cui X, Fang N, Wu Y, Yu S, Xiao D. Methionine‐CBS axis promotes intracellular ROS levels by reprogramming serine metabolism. FASEB J. 2023;37:e23268. https://doi.org/10.1096/fj.202300804RRRR. The above article, published online on 27 October 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief, Loren E. Wold, the Federation of American Societies for Experimental Biology, and Wiley Periodicals LLC. The retraction has been agreed upon per the authors' request to retract the article, as they found that the data presented in Figure 3 are insufficient to support one of the key conclusions of the paper, that methionine deficiency alters the flow of serine metabolism. The authors apologize for the oversight. [ABSTRACT FROM AUTHOR]