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2. Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells.

Author

Guangdong Yang, Lingyun Wu, and Rui Wang

Subjects
*CELL proliferation, *MITOGEN-activated protein kinases, *APOPTOSIS, *MUSCLE cells, *SMOOTH muscle
Abstract

Presents findings of a study which tested the hypothesis that endogenously produced H2S plays a fundamental role in cell proliferation and survival. Effect of overexpressed cystathione gamma-lyase (CSE) on H2S production and human aorta smooth muscle cell (HASMC); Role of CSE overexpression in activating mitogen-activated protein kinases and cell cycle proteins; Approach used in exploring the effect of CSE on HASMC apoptosis.

Published
2006
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3. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3.

Author

Guangdong Yang, Xianfeng Sun, and Rui Wang

Subjects
*HYDROGEN sulfide, *APOPTOSIS, *CELLULAR signal transduction, *SMOOTH muscle, *MUSCLE cells, *PHOSPHORYLATION, *PROTEIN kinases
Abstract

Discusses a study which examined the physiological role of hydrogen sulfide in the regulation of cellular apoptosis and underlying cellular signal transduction pathways. Effect of endogenous and exogenous hydrogen sulfide on human aortic smooth muscle cell apoptosis; Influence of hydrogen sulfide on the phosphorylation and activation of mitogen-activated protein kinases; Schematic signal transduction pathways underlying the hydrogen sulfide-induced apoptosis.

Published
2004
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