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1. The ectodomain shedding of CD30 is specifically regulated by peptide motifs in its cysteine-rich domains 2 and 5.

Author

Hansen, Hinrich P., Recke, Andreas, Reineke, Ulrich, Von Tresckow, Bastian, Borchmann, Peter, Von Strandmann, Elke Pogge, Lange, Hans, Lemke, Hilmar, and Engert, Andreas

Subjects
*TUMOR necrosis factors, *CYTOKINES, *GROWTH factors, *ENZYMES, *ENZYMOLOGY
Abstract

Focuses on the shedding-influencing role of structural elements of the ectodomain of CD30, a known substrate of tumor necrosis factorα-converting enzyme. Antibody-dependent inhibition of CD30 shedding; Regulation of the releasing enzyme in a feedback fashion by the soluble product through competitive inhibition; Modulation of sCD30 release by the cleavage product.

Published
2004
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