1. Rebamipide suppresses TNF-α mediated inflammation in vitro and attenuates the severity of dermatitis in mice.
- Author
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Li, Weiwei, Zhao, Yunpeng, Xu, Xiangling, Ma, Weiyuan, Gao, Peng, Wang, Yan, Liang, Ke, and Li, Ruifeng
- Subjects
AMINO acid derivatives ,TUMOR necrosis factors ,SKIN inflammation ,GASTRITIS ,CELLULAR signal transduction ,LABORATORY mice ,THERAPEUTICS - Abstract
Rebamipide is a routine drug for the treatment of gastritis in a clinical setting. Recently, it has been shown to protect against various inflammatory diseases, and has provided a potential therapy for these diseases. However, whether rebamipide has a role in dermatitis remains to be elucidated. Here, we found that rebamipide alleviated the inflammatory reaction induced by tumor necrosis factor-α in RAW264.7, a stable macrophage cell line. Furthermore, rebamipide treatment repressed activation of nuclear factor-kappaB signaling, a well-established inflammatory signaling pathway. Moreover, an oxazolone-induced dermatitis mouse model was established to investigate the role of rebamipide in vivo. PBS control group exhibited typical skin inflammation, whereas treatment with rebamipide remarkably attenuated a dermatitis phenotype in this mouse model. The protective role of rebamipide in dermatitis in vivo was probably due to its inhibition of nuclear factor-kappaB signaling. Collectively, rebamipide may represent a promising molecular target for the prevention and treatment of inflammatory skin diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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