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Your search keyword '"Liu, Chuan"' showing total 2 results
2 results on '"Liu, Chuan"'

1. Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice.

Author

Zhao, Yun-Peng, Tian, Qing-Yun, and Liu, Chuan-Ju

Subjects
PROGRANULIN, PROTEIN deficiency, SKIN inflammation, GENE expression, CYCLOOXYGENASE 2, NF-kappa B, LABORATORY mice
Abstract

Highlights: [•] PGRN expression was upregulated in inflammatory skin. [•] PGRN deficiency exaggerated, while Atsttrin attenuated, dermatitis in mice. [•] PGRN/Atsttrin may protect against dermatitis through inhibition of NF-κB signaling. [ABSTRACT FROM AUTHOR]

Published
2013
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2. PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells

Author

Gu, Zhi-Min, Liu, Chuan-Xu, Wu, Shao-Fang, Zhao, Meng, Xu, Han-Zhang, Liu, Wei, Zhou, Hu-Chen, Chen, Guo-Qiang, and Wu, Ying-Li

Subjects
*TRETINOIN, *INTERFERONS, *LEUKEMIA, *GENE expression, *LUCIFERASES, *BINDING sites, *TRANSCRIPTION factors
Abstract

Abstract: RIG-G is a retinoic acid- or interferon-induced gene with potential anti-proliferation function. However, the mechanism underlying ATRA-induced RIG-G induction is not completely understood. Here, we demonstrate that ATRA up-regulates the expression of PU.1, which in turn directly binds to the promoter and increases the expression of RIG-G gene. Luciferase reporter assay and electrophoretic mobility shift assay reveal that PU.1 preferentially binds to one of the two putative binding sites on the RIG-G promoter. Moreover, silencing of PU.1 by shRNA markedly inhibited ATRA- but not IFNα-induced expression of RIG-G. These data provide new insight into the mechanism of ATRA-induced RIG-G expression. [ABSTRACT FROM AUTHOR]

Published
2011
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