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1. miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6.

Author

Li, Ruotian, Yan, Guijun, Zhang, Qun, Jiang, Yue, Sun, Haixiang, Hu, Yali, Sun, Jianxin, and Xu, Biao

Subjects
MICRORNA, ISOPROTERENOL, HEART cells, CARDIAC hypertrophy, GENE expression, TRANSCRIPTION factors, CHROMOSOMAL translocation
Abstract

Highlights: [•] miR-145 protects against cardiomyocyte hypertrophy induced by the βAR agonist ISO. [•] GATA6 is a direct functional target gene of miR-145. [•] miR-145 attenuates GATA6 nuclear translocation through inhibition of GSK3β phosphorylation. [ABSTRACT FROM AUTHOR]

Published
2013
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