1. Arginine methylation of hnRNP K enhances p53 transcriptional activity
- Author
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Chen, Yibin, Zhou, Xinyuan, Liu, Na, Wang, Chaochen, Zhang, Liang, Mo, Wei, and Hu, Gengxi
- Subjects
ARGININE ,METHYLATION ,ULTRAVIOLET radiation ,DNA damage ,AMINO acids - Abstract
Abstract: Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity. [Copyright &y& Elsevier]
- Published
- 2008
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