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Your search keyword '"Ceramide synthase 2"' showing total 2 results
Start Over Descriptor "Ceramide synthase 2" Journal febs letters
2 results on '"Ceramide synthase 2"'

1. LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme.

Author

Ali, Mohammad, Saroha, Ashish, Pewzner-Jung, Yael, and Futerman, Anthony H.

Subjects
*LIPOPOLYSACCHARIDES, *SEPTIC shock, *CERAMIDES, *TUMOR necrosis factors, *CYTOKINES, *LABORATORY mice
Abstract

Tumor necrosis factor α (TNFα) is an inflammatory cytokine that plays an intimate role in septic shock. Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30 h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very-long acyl chain ceramides, die within ∼10 h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNFα secretion as a result of enhanced activity of TNFα-converting enzyme (TACE). We discuss the relationship between the sphingolipid acyl chain length and TACE activity and the relevance of this data to septic shock. [ABSTRACT FROM AUTHOR]

Published
2015
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2. LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

Author

Yael Pewzner-Jung, Mohammed K. Ali, Anthony H. Futerman, and Ashish Saroha

Subjects
Lipopolysaccharides, Ceramide, medicine.medical_specialty, Lipopolysaccharide, medicine.medical_treatment, Blotting, Western, Biophysics, Gene Expression, ADAM17 Protein, Biology, Bone marrow-derived macrophage, Ceramides, Biochemistry, Sphingolipid, LPS-mediated sepsis, chemistry.chemical_compound, Structural Biology, Internal medicine, Sphingosine N-Acyltransferase, Genetics, medicine, Animals, Tumor necrosis factor α, Molecular Biology, Cells, Cultured, Mice, Knockout, Sphingolipids, Microscopy, Confocal, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, Septic shock, Macrophages, Ceramide synthase 2, Cell Biology, medicine.disease, Shock, Septic, Tumor necrosis factor α converting enzyme, 3. Good health, ADAM Proteins, Endocrinology, Cytokine, chemistry, Hepatocytes, Tumor necrosis factor alpha
Abstract

Tumor necrosis factor α (TNFα) is an inflammatory cytokine that plays an intimate role in septic shock. Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very-long acyl chain ceramides, die within ∼10h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNFα secretion as a result of enhanced activity of TNFα-converting enzyme (TACE). We discuss the relationship between the sphingolipid acyl chain length and TACE activity and the relevance of this data to septic shock.

Full Text
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