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2. Preferential interaction of the Alzheimer peptide Aβ-(1-42) with Omega-3-containing lipid bilayers: structure and interaction studies

Author

Delia Picone, Augusta De Santis, Roberta Spadaccini, Gerardino D'Errico, Remo Guerrini, Alessandro Emendato, Emendato, Alessandro, Spadaccini, Roberta, DE SANTIS, Augusta, Guerrini, Remo, D'Errico, Gerardino, and Picone, Delia

Subjects
0301 basic medicine, Circular dichroism, Amyloid beta-Peptide, Protein Conformation, amyloid β-peptide (1-42), Lipid Bilayers, Peptide, Omega-3 lipids, Biochemistry, 0302 clinical medicine, Protein structure, Peptide Fragment, Structural Biology, Biomimetic Materials, Lipid bilayer, Peptide sequence, Docosahexaenoic Acid, chemistry.chemical_classification, Chemistry, Medicine (all), Circular Dichroism, peptide-membrane interaction, Docosahexaenoic acid, Omega-3 lipid, Alzheimer's disease, Biomimetic Material, Human, Polyunsaturated fatty acid, Docosahexaenoic Acids, Molecular Sequence Data, Biophysics, NO, 03 medical and health sciences, Genetic, Alzheimer Disease, Abeta toxic oligomers, Alzheimer disease, biomimetic lipid bilayers, peptide-membrane interactions, Fatty Acids, Omega-3, Genetics, medicine, Humans, Amino Acid Sequence, Molecular Biology, Amyloid beta-Peptides, Electron Spin Resonance Spectroscopy, Cell Biology, Abeta toxic oligomer, medicine.disease, Peptide Fragments, 030104 developmental biology, Biophysic, Solubility, Lipid Bilayer, biomimetic lipid bilayer, 030217 neurology & neurosurgery
Abstract

Many age-related neurodegenerative diseases, including Alzheimer Disease (AD), are elicited by an interplay of genetic, environmental, and dietary factors. Food rich in Omega-3 phospholipids seems to reduce the AD incidence. To investigate the molecular basis of this beneficial effect, we have investigated by CD and ESR studies the interaction between the Alzheimer peptide Ab-(1–42) and biomimetic lipid bilayers. The inclusion of 1,2-didocosahexaenoyl-sn-glycero-3-phosphocholine does not change significantly the bilayers organization, but favors its Ab-(1–42) interaction. The Omega-3 lipid amount modulates the effect intensity, suggesting a peptide selectivity for membranes containing polyunsatured fatty acids (PUFA) and providing hints for the mechanism and therapy of AD.

Published
2015

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