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1. Oxidation of N(G)-hydroxyl-L-arginine to nitric oxide mediated by respiratory burst: an alternative pathway to NO synthesis

Author

Klaus Eichmann, Germán Soler, and Manuel Modolell

Subjects
Phagocyte, Arginine, Metabolite, Biophysics, Nitric Oxide, Biochemistry, Nitric oxide, chemistry.chemical_compound, Mice, Downregulation and upregulation, Structural Biology, Superoxides, Genetics, medicine, Animals, Humans, Superoxide anion, Hydroxy-l-arginine, Molecular Biology, Cells, Cultured, Nitrites, Respiratory Burst, Phagocytes, biology, Superoxide, Cell Biology, Respiratory burst, Nitric oxide synthase, Mice, Inbred C57BL, medicine.anatomical_structure, chemistry, biology.protein, Nitric Oxide Synthase, Oxidation-Reduction
Abstract

NG-Hydroxy- l -arginine is an intermediate metabolite in the synthesis of nitric oxide that is upregulated and secreted during acute inflammation in vivo. Previous reports have shown that chemically induced superoxide anion oxidizes NG-hydroxy- l -arginine to nitric oxide. Here, we demonstrate that this reaction takes place physiologically in phagocytic cells during the respiratory burst, and is independent of the presence of nitric oxide synthase.

Published
1997

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