1. Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1
- Author
-
Yiming Chang, Veit Flockerzi, Andreas Beck, and Gabriel Schlenstedt
- Subjects
Saccharomyces cerevisiae Proteins ,Intracellular Space ,Biophysics ,Saccharomyces cerevisiae ,Transient receptor potential channel ,Biochemistry ,Yeast vacuolar conductance 1 ,TRPC1 ,Transient Receptor Potential Channels ,Structural Biology ,Genetics ,Animals ,Tonoplast recording ,Molecular Biology ,Peptide sequence ,Gene ,Ion channel ,TRPC Cation Channels ,Calcium release ,biology ,Chlamydomonas ,Electric Conductivity ,Cell Biology ,biology.organism_classification ,Yeast ,Transmembrane domain ,Yeast cation channel ,Phenotype ,Calcium Channels - Abstract
Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas, and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, and adjacent domains. In the yeast genome, there is one gene encoding a TRP-like sequence. This protein forms an ion channel in the vacuolar membrane and is therefore called Yvc1 for yeast vacuolar conductance 1. In the following we summarize its prominent features.
- Published
- 2009