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Your search keyword '"Agnieszka Rombel‐Bryzek"' showing total 3 results
Start Over Author "Agnieszka Rombel‐Bryzek" Journal febs open bio
3 results on '"Agnieszka Rombel‐Bryzek"'

1. Thermodynamic analysis of the interactions between human ACE2 and spike RBD of Betacoronaviruses (SARS‐CoV‐1 and SARS‐CoV‐2)

Author

Agnieszka Rombel‐Bryzek, Adriana Miller, and Danuta Witkowska

Subjects
binding interactions, human ACE2, isothermal titration alorimetry, receptor‐binding domain, SARS‐CoV‐1, SARS‐CoV‐2, Biology (General), QH301-705.5
Abstract

There are many scientific reports on the interaction of the SARS‐CoV‐2 virus S protein (and its RBD) with the human ACE2 receptor protein. However, there are no reliable data on how this interaction differs from the interaction of the receptor binding domain of SARS‐CoV‐1 with ACE2, in terms of binding strength and changes in reaction enthalpy and entropy. Our studies have revealed these differences and the impact of zinc ions on this interaction. Intriguingly, the binding affinity of both RBDs (of SARS‐CoV‐1 and of SARS‐CoV‐2) to the ACE2 receptor protein is almost identical; however, there are some differences in the entropic and enthalpic contributions to these interactions.

Published
2023
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3. Thermodynamic analysis of the interactions between human ACE2 and Spike RBD of Betacoronaviruses (SARS-CoV-1 and SARS-CoV-2)

Author

Agnieszka, Rombel-Bryzek, Adriana, Miller, and Danuta, Witkowska

Abstract

There are many scientific reports on the interaction of the SARS-CoV-2 virus S protein (and its RBD) with the human ACE2 receptor protein. However, there are no reliable data on how this interaction differs from the interaction of the receptor binding domain of SARS-CoV-1 with ACE2, in terms of binding strength and changes in reaction enthalpy and entropy. Our studies have revealed these differences as well as the impact of zinc ions on this interaction. Intriguingly, the binding affinity of both RBDs (of SARS-CoV-1 and of SARS-CoV-2) to the ACE2 receptor protein is almost identical; however, there are some differences in the entropic and enthalpic contributions to these interactions.

Published
2022

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