1. MafB deficiency accelerates the development of obesity in mice
- Author
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Yuki Tsunakawa, Michito Hamada, Yuan‐Yu Lin, Satoru Takahashi, Kumiko Fujisawa, Hyojung Jeon, Kaushalya Kulathunga, Mai Thi Nhu Tran, Risa Kamei, Takashi Kudo, and Megumi Nakamura
- Subjects
0301 basic medicine ,obesity ,medicine.medical_specialty ,Apoptosis Inhibitor ,Adipose tissue macrophages ,apoptosis inhibitor of macrophage ,Adipose tissue ,Biology ,General Biochemistry, Genetics and Molecular Biology ,MafB ,03 medical and health sciences ,chemistry.chemical_compound ,Haematopoiesis ,030104 developmental biology ,Endocrinology ,chemistry ,MAFB ,Internal medicine ,Adipocyte ,Lipogenesis ,medicine ,Macrophage ,adipose tissue macrophages ,Research Articles ,Research Article - Abstract
MafB, a transcription factor expressed selectively in macrophages, has important roles in some macrophage-related diseases, especially in atherosclerosis. In this study, we investigated the mechanism by which hematopoietic-specific MafB deficiency induces the development of obesity. Wild-type and hematopoietic cell-specific Mafb-deficient mice were fed a high-fat diet for 10 weeks. The Mafb-deficient mice exhibited higher body weights and faster rates of body weight increase than control mice. The Mafb-deficient mice also had a higher percentage of body fat than the wild-type mice, due to increased adipocyte size and serum cholesterol levels. Reverse transcription-PCR analysis showed a reduction in apoptosis inhibitor of macrophage (AIM) in Mafb-deficient adipose tissue. AIM is known as an inhibitor of lipogenesis in adipocytes and is expressed in adipose tissue macrophages. Collectively, our data suggest that Mafb deficiency in hematopoietic cells accelerates the development of obesity.
- Published
- 2016