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Your search keyword '"Mok-Lin, E."' showing total 28 results
Start Over Author "Mok-Lin, E." Journal fertility and sterility
28 results on '"Mok-Lin, E."'

27. Bisphenol A and ovarian steroidogenesis.

Author

Bloom MS, Mok-Lin E, and Fujimoto VY

Subjects
Animals, Female, Humans, Ovary enzymology, Ovary physiopathology, Risk Assessment, Risk Factors, Endocrine Disruptors adverse effects, Environmental Exposure adverse effects, Environmental Pollutants adverse effects, Estrogens biosynthesis, Ovary drug effects, Reproduction drug effects
Abstract

Bisphenol A is widely used as a component in polycarbonate plastics for food and beverage packaging, epoxy linings for canned foods, and dental sealants, among other applications. Experimental literature demonstrates BPA's affinity for estrogen receptors and downstream effects on estrogen-responsive genes. Additional data suggest that BPA reduces endogenous estrogen synthesis, likely by antagonizing ovarian enzyme activities involved in sex-steroid hormone synthesis. More specifically, evidence indicates BPA-mediated disruption of STAR, CYP450scc, and HSD-3β in theca cells and CYP450 aromatase activity in granulosa cells. Yet the results of the few human studies reported to date are equivocal. It also remains in question the extent to which BPA penetrates developing ovarian follicles. Uncertainty as to the relevance of experimental BPA doses and administration routes for common human exposure levels limits extrapolation of experimental results. To more definitively address the potential risk of BPA on human ovarian steroidogenesis, additional experimental studies using biologically active BPA doses likely to reflect those within the ovarian follicle will be necessary, as will additional prospective investigations in human populations with the use of standardized assay methodology., (Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2016
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28. Public perceptions of providing IVF services to cancer and HIV patients.

Author

Mok-Lin E, Missmer S, Berry K, Lehmann LS, and Ginsburg ES

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Attitude to Health, Data Collection, Female, Health Services Accessibility, Humans, Infertility therapy, Male, Middle Aged, Patient Rights, Surveys and Questionnaires, United States, Young Adult, Fertilization in Vitro, HIV Infections psychology, Infertility psychology, Neoplasms psychology, Public Opinion
Abstract

Objective: To assess the attitudes of the general U.S. population toward the use of IVF to assist adults with a history of cancer or human immunodeficiency virus (HIV)., Design: Cross-sectional survey study., Setting: Online., Patient(s): A total of 1,183 adult men and women across the U.S., Intervention(s): Questionnaire consisting of multiple-choice and open-ended questions., Main Outcome Measure(s): Attitudes toward IVF for cancer and HIV patients., Result(s): A total of 82% supported IVF for cancer patients compared with 38% for HIV patients. The most common reasons for support was the anticipation of normal life expectancies and a belief in the universal right to have children, although nearly twice as many participants believed this to be a "right" for cancer patients than for HIV patients. Young respondent ages, higher educational attainment, Jewish religion, and a personal history of infertility were associated with higher likelihood of support. Lower education level, higher annual household income, and having children were predictors of discordance in support of IVF for cancer versus HIV patients., Conclusion(s): Despite advancements in the treatment of cancer and HIV, which have allowed patients to have longer life expectancies and improved chances of parenthood, there is significant disparity in the support of providing IVF to these patient groups., (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2011
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