1. Human oocyte cryopreservation with slow freezing versus vitrification. Results from the National Italian Registry data, 2007-2011
- Author
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Giulia Scaravelli, Paolo Emanuele Levi Setti, Roberto De Luca, Paola D'Aloja, Pasquale Patrizio, Vincenzo Vigiliano, Roberta Spoletini, Eleonora Porcu, Levi Setti, Pe, Porcu, E, Patrizio, P, Vigiliano, V, de Luca, R, D'Aloja, P, Spoletini, R, and Scaravelli, G
- Subjects
medicine.medical_specialty ,Time Factors ,Pregnancy Rate ,Oocyte Retrieval ,Fertilization in Vitro ,Cryopreservation ,Andrology ,Human fertilization ,Pregnancy ,medicine ,Humans ,Vitrification ,Embryo Implantation ,Registries ,Survival rate ,Retrospective Studies ,Oocyte, Cryopreservation, slow freezing, vitrification, IVF ,Gynecology ,business.industry ,Obstetrics and Gynecology ,Retrospective cohort study ,Oocyte cryopreservation ,Oocyte ,Embryo Transfer ,Pregnancy rate ,medicine.anatomical_structure ,Treatment Outcome ,Reproductive Medicine ,Italy ,Infertility ,Oocytes ,Female ,business ,Live Birth - Abstract
OBJECTIVE: To compare mature human oocytes cryopreservation with slow freezing (SF) and vitrification (VT) in infertile couples. DESIGN: Retrospective study of national Italian data submitted during the period 2007-2011. SETTING: National ART registry. PATIENT(S): Infertile patients with supernumerary oocytes. INTERVENTION(S): Thawing or warming of cryopreserved oocytes and ICSI. MAIN OUTCOME MEASURE(S): oocyte survival, fertilization, implantation and clinical pregnancy rate between SF and VT. RESULT(S): A total of 14,328 cycles with 11,599 transfers, 1,850 pregnancies, 1,168 deliveries and 1,342 babies born were analyzed from 146 reporting centers (range of cycles 1-1,255 per center). The SF oocytes' survival rate was lower than in VT (51.1% vs. 63.1%). Fertilization rate was significantly higher in SF than in VT (SF 71.6% vs. VT 70.1%). VT showed a significantly higher pregnancy rate, both per started cycle (14.4% vs. 12.0%) and per transfer (18.0% vs. 14.8%), and implantation rate (9.5% vs. 8.1%) than SF. However, the range and median pregnancy rate per started cycle were, respectively, 0%-50% and 7.7% in SF and 0%-100% and 6.7% in VT. CONCLUSION(S): VT showed a statistically significant higher performance than SF. As with other ART procedures, the results are not homogeneous among clinics and protocols, but the confirm the clinical value of oocyte cryopreservation in infertile patients.
- Published
- 2014