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Your search keyword '"Pituitary deficiency"' showing total 3 results
Start Over Descriptor "Pituitary deficiency" Journal fertility and sterility
3 results on '"Pituitary deficiency"'

1. Pregnancy outcomes in women with growth hormone deficiency

Author

Anders F Mattsson, Michaela Riedl, Greisa Vila, Anton Luger, Vaclav Hana, Susan M. Webb, Ann-Charlotte Åkerblad, Eigil Husted Nielsen, and Beverly M. K. Biller

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Databases, Factual, Reproductive Techniques, Assisted, Hormone Replacement Therapy, Gestational Age, Hypopituitarism, Drug Administration Schedule, Growth hormone deficiency, Young Adult, pituitary tumors, Pregnancy, Risk Factors, medicine, Outpatient clinic, Birth Weight, Humans, pituitary deficiency, Prospective Studies, Growth hormone, Obstetrics, business.industry, Human Growth Hormone, Pregnancy Outcome, Obstetrics and Gynecology, Gestational age, Middle Aged, medicine.disease, United States, Europe, Pregnancy Complications, hormone replacement therapy, Reproductive Medicine, Transgender hormone therapy, Gestation, Female, pregnancy, Live birth, business, Live Birth, Biomarkers
Abstract

Objective: To study pregnancies in a large group of patients with growth hormone deficiency and hypopituitarism; and to investigate potential factors determining pregnancy outcomes and pregnancy complications. Design: We analyzed pregnancies reported in KIMS, the Pfizer International Metabolic Database, of adult patients with growth hormone deficiency treated with growth hormone. Setting: Outpatient clinics. Patient(s): A total of 201 pregnancies were reported: 173 in female patients and 28 in partners of male patients. Intervention(s): Growth hormone replacement therapy (GHRT) was prescribed according to the local clinical practice. Main Outcome Measure(s): Pregnancy outcomes (live births, gestational week at delivery, and birth weight), pregnancy complications, and their relationship to use of GHRT during pregnancy were analyzed with regression models. Result(s): Two-thirds of women underwent fertility treatment to achieve pregnancy. Growth hormone replacement therapy was stopped before pregnancy in 7.5% of the female patients, as soon as pregnancy was confirmed in 40.1%, and at the end of the second trimester in 24.7% of the patients, whereas 27.6% continued GHRT throughout pregnancy. Birth of a healthy child was reported in 79% of the female pregnancies, nonelective abortions occurred mainly in the first trimester, and one fetal malformation (cystic hygroma) was diagnosed in the second trimester. Pregnancy outcomes and pregnancy complications were not related to GHRT treatment patterns, method of conception, or number of additional pituitary deficiencies. Conclusion(s): These data on pregnancy outcomes in a large group of women with hypopituitarism revealed no relationship between GHRT regimens and pregnancy outcomes. (C) 2015 by American Society for Reproductive Medicine.

Published
2015

2. Hypothalamic-pituitary deficiency after Weil's syndrome: a case report

Author

Sotirios Skiadopoulos, David Rousso, Dimitrios Panidis, Achilleas Kalogeropoulos, and Dimitrios Vavilis

Subjects
Adult, Male, medicine.medical_specialty, Hydrocortisone, Pituitary Diseases, Thyrotropin-releasing hormone, Gonadotropin-releasing hormone, Hypothalamic disease, Chorionic Gonadotropin, Clomiphene, Gonadotropin-Releasing Hormone, Pituitary deficiency, Leptospira, Internal medicine, medicine, Humans, Insulin, Testosterone, Thyrotropin-Releasing Hormone, S syndrome, biology, business.industry, Hypogonadism, Obstetrics and Gynecology, Luteinizing Hormone, biology.organism_classification, medicine.disease, Leptospirosis, Prolactin, Thyroxine, Endocrinology, Reproductive Medicine, Hypothalamus, Growth Hormone, Follicle Stimulating Hormone, business, Hypothalamic Diseases, Weil Disease
Abstract

A case of male hypogonadism after Weil's syndrome is described. Hypogonadism was the result of complete hypothalamic-pituitary deficiency. The relationship between leptospirosis and the endocrinopathy, the incidence that leptospira attacks hypothalamic-pituitary axis, and the mechanism with which the microorganism may cause damage to the pituitary and/or the hypothalamus are discussed.

Published
1994

3. Pregnancy outcomes in women with growth hormone deficiency.

Author

Vila G, Akerblad AC, Mattsson AF, Riedl M, Webb SM, Hána V, Nielsen EH, Biller BM, and Luger A

Subjects
Adolescent, Adult, Biomarkers blood, Birth Weight, Databases, Factual, Drug Administration Schedule, Europe, Female, Gestational Age, Hormone Replacement Therapy adverse effects, Human Growth Hormone administration & dosage, Human Growth Hormone adverse effects, Human Growth Hormone blood, Humans, Hypopituitarism blood, Hypopituitarism diagnosis, Hypopituitarism drug therapy, Live Birth, Male, Middle Aged, Pregnancy, Pregnancy Complications etiology, Prospective Studies, Reproductive Techniques, Assisted, Risk Factors, Time Factors, United States, Young Adult, Human Growth Hormone deficiency, Hypopituitarism complications, Pregnancy Outcome
Abstract

Objective: To study pregnancies in a large group of patients with growth hormone deficiency and hypopituitarism; and to investigate potential factors determining pregnancy outcomes and pregnancy complications., Design: We analyzed pregnancies reported in KIMS, the Pfizer International Metabolic Database, of adult patients with growth hormone deficiency treated with growth hormone., Setting: Outpatient clinics., Patient(s): A total of 201 pregnancies were reported: 173 in female patients and 28 in partners of male patients., Intervention(s): Growth hormone replacement therapy (GHRT) was prescribed according to the local clinical practice., Main Outcome Measure(s): Pregnancy outcomes (live births, gestational week at delivery, and birth weight), pregnancy complications, and their relationship to use of GHRT during pregnancy were analyzed with regression models., Result(s): Two-thirds of women underwent fertility treatment to achieve pregnancy. Growth hormone replacement therapy was stopped before pregnancy in 7.5% of the female patients, as soon as pregnancy was confirmed in 40.1%, and at the end of the second trimester in 24.7% of the patients, whereas 27.6% continued GHRT throughout pregnancy. Birth of a healthy child was reported in 79% of the female pregnancies, nonelective abortions occurred mainly in the first trimester, and one fetal malformation (cystic hygroma) was diagnosed in the second trimester. Pregnancy outcomes and pregnancy complications were not related to GHRT treatment patterns, method of conception, or number of additional pituitary deficiencies., Conclusion(s): These data on pregnancy outcomes in a large group of women with hypopituitarism revealed no relationship between GHRT regimens and pregnancy outcomes., (Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2015
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