1. Normalisation of Angiogenic Imbalance after Intra-Uterine Transfusion for Mirror Syndrome Caused by Parvovirus B19.
- Author
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Goa, Satoko, Mimura, Kazuya, Kakigano, Aiko, Tomimatsu, Takuji, Kinugasa-Taniguchi, Yukiko, Endo, Masayuki, Kanagawa, Takeshi, and Kimura, Tadashi
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INTRAUTERINE blood transfusion , *NEOVASCULARIZATION , *PATHOLOGICAL physiology , *ECLAMPSIA , *PARVOVIRUSES , *PLACENTAL growth factor , *CHORIONIC gonadotropins , *PROTEIN-tyrosine kinases - Abstract
We report a case of mirror syndrome caused by parvovirus B19, which resolved after intra-uterine transfusion. Mirror syndrome is a rare condition characterised by a triad of foetal hydrops, generalized maternal oedema and placentomegaly. Although the mechanism underlying the onset of this syndrome is unknown, it probably shares a common pathophysiologic origin with pre-eclampsia. Our patient showed increased circulating levels of soluble fms-like tyrosine kinase 1 (sFlt-1) and decreased levels of placental growth factor (PlGF), which have also been reported in pre-eclampsia. The sFlt-1/PlGF ratio decreased immediately after intra-uterine transfusion, followed by resolution of both maternal and foetal symptoms. This suggests that the sFlt-1/PlGF ratio may help to predict the post-treatment course of mirror syndrome. Copyright © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2013
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