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1. Fetal Cardiac Intervention for Pulmonary Atresia with Intact Ventricular Septum: International Fetal Cardiac Intervention Registry

Author

Renuka E. Peterson, Roland Devlieger, Shaine A. Morris, Queralt Ferrer, Gary F. Sholler, Sarah Gelehrter, Dick Oepkes, John M. Simpson, Joanna Dangel, Aimee K. Armstrong, Alberto Galindo, Edgar Jaeggi, Joana O. Miranda, Michele A. Frommelt, Annette Wacker-Gussmann, James Strainic, Helena M. Gardiner, Lisa Howley, Ulrike Herberg, Trisha V Vigneswarran, Simone Rolim Fernandes Fontes Pedra, Whitnee Hogan, Sofía Grinenco, and Anita J. Moon-Grady

Subjects
Embryology, medicine.medical_specialty, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Pregnancy, Fetus, 030219 obstetrics & reproductive medicine, Tricuspid valve, Fetal cardiac intervention, Fetal echocardiography, medicine.diagnostic_test, business.industry, Congenital heart defect, Pulmonary atresia with intact ventricular septum, Obstetrics and Gynecology, Gestational age, General Medicine, medicine.disease, Stenosis, Valvuloplasty, medicine.anatomical_structure, Pulmonary valve, Pediatrics, Perinatology and Child Health, Cardiology, business, Pulmonary atresia
Abstract

Introduction: Invasive fetal cardiac intervention (FCI) for pulmonary atresia with intact ventricular septum (PAIVS) and critical pulmonary stenosis (PS) has been performed with small single-institution series reporting technical and physiological success. We present the first multicenter experience. Objectives: Describe fetal and maternal characteristics of those being evaluated for FCI, including pregnancy/neonatal outcome data using the International Fetal Cardiac Intervention Registry (IFCIR). Methods: We queried the IFCIR for PAIVS/PS cases evaluated from January 2001 to April 2018 and reviewed maternal/fetal characteristics, procedural details, pregnancy and neonatal outcomes. Data were analyzed using standard descriptive statistics. Results: Of the 84 maternal/fetal dyads in the registry, 58 underwent pulmonary valvuloplasty at a median gestational age of 26.1 (21.9–31.0) weeks. Characteristics of fetuses undergoing FCI varied in terms of tricuspid valve (TV) size, TV regurgitation, and pulmonary valve patency. There were fetal complications in 55% of cases, including 7 deaths and 2 delayed fetal losses. Among those who underwent successful FCI, the absolute measurement of the TV increased by 0.32 (±0.17) mm/week from intervention to birth. Among 60 liveborn with known outcome, there was a higher percentage having a biventricular circulation following successful FCI (87 vs. 43%). Conclusions: Our data suggest a possible benefit to fetal therapy for PAIVS/PS, though rates of technically unsuccessful procedures and procedure-related complications, including fetal loss were substantial. FCI criteria are extremely variable, making direct comparison to nonintervention patients challenging and potentially biased. More uniform FCI criteria for fetuses with PAIVS/PS are needed to avoid unnecessary procedures, expose only fetuses most likely to sustain a benefit, and to enable comparisons to be made with nonintervention patients.

Published
2020

2. Sudden Fetal Hematologic Changes as a Complication of Amnioreduction in Twin-Twin Transfusion Syndrome

Author

Katarzyna Kosinska-Kaczynska, Michal Lipa, Robert Brawura-Biskupski-Samaha, Iwona Szymusik, Miroslaw Wielgos, Enrico Lopriore, Lisanne S.A. Tollenaar, Szymon Kozlowski, Dorota Bomba-Opoń, and Dick Oepkes

Subjects
Adult, Male, Embryology, medicine.medical_specialty, Amnioreduction, Decompression, Anemia, Twin-twin transfusion syndrome, 030204 cardiovascular system & hematology, Anastomosis, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Placenta, medicine, Humans, Radiology, Nuclear Medicine and imaging, Monochorionic twins, Fetus, 030219 obstetrics & reproductive medicine, business.industry, Fetoscopy, Hemodynamics, Obstetrics and Gynecology, Fetofetal Transfusion, General Medicine, medicine.disease, Surgery, Fetal therapy, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Gestation, Female, Complication, business
Abstract

We present the first case of a monochorionic twin pregnancy in which sudden hematologic changes occurred as a complication of the amnioreduction procedure for twin-twin transfusion syndrome (TTTS). At 33 weeks of gestation, 4 days after the amnioreduction, the recipient developed severe anemia while the donor developed severe polycythemia. Postnatal placental examination revealed several arteriovenous and venoarterial anastomoses, a pale placental mass of the recipient and a congested and plethoric placental mass of the donor. We speculate on the pathophysiologic changes and potential deleterious effects provoked by the decompressive amnioreduction. Decompression of the placenta and anastomoses after the amnioreduction may have led to an acute blood shift from recipient to donor (thus also a reversal of feto-fetal transfusion), resulting in anemia in the recipient and polycythemia in the donor twin. In the past 15 years, 13 TTTS cases with late presentation were treated with amnioreduction. This is the first time we encountered this severe complication, yielding an incidence of 8%. Although the optimal treatment in TTTS with late presentation is not known, perinatologists should be aware that treatment with amnioreduction can lead to sudden hematologic changes.

Published
2018

3. Short-Term Postnatal Renal Function in Twin Anemia-Polycythemia Sequence

Author

Gianluca Lista, Lianne Verbeek, Enrico Lopriore, Dick Oepkes, Marine Vieujoz, Romain Favre, Femke Slaghekke, and Francesco Cavigioli

Subjects
Embryology, Pediatrics, medicine.medical_specialty, Renal function, Twin-twin transfusion syndrome, Gestational Age, Polycythemia, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Reticulocyte Count, Pregnancy, Humans, Urea, Medicine, Twin Anemia-Polycythemia Sequence, Radiology, Nuclear Medicine and imaging, Monochorionic twins, 030212 general & internal medicine, Twin Twin Transfusion Syndrome, Retrospective Studies, Creatinine, 030219 obstetrics & reproductive medicine, business.industry, Twin anemia-polycythemia sequence, Obstetrics and Gynecology, Gestational age, Retrospective cohort study, Fetofetal Transfusion, General Medicine, Creatine, medicine.disease, chemistry, Pediatrics, Perinatology and Child Health, Premature Birth, Female, business
Abstract

Objective: To evaluate the short-term renal function in neonates with twin anemia-polycythemia sequence (TAPS). Methods: All consecutive monochorionic twins with TAPS with double survivors admitted to three European centers were included in this retrospective study. Each twin pair was matched for gestational age at birth with a control twin pair unaffected by TAPS or twin-twin transfusion syndrome. Creatinine and urea levels in the first week after birth were recorded. Short-term postnatal renal dysfunction was defined as creatinine >100 μmol/l during the first week after birth. Results: A total of 52 TAPS twin pairs and 52 control twin pairs with a median gestational age of 31 weeks at birth were included in the study. In the TAPS group, donors had higher mean creatinine levels compared to recipients, 85 versus 71 μmol/l, respectively (p = 0.001). Short-term renal dysfunction was detected in 26.0% (13/50) of the donors versus 6.3% (3/48) of the recipients (p = 0.022). In the control group, no inter-twin differences in creatinine levels were found. Conclusions: Donor twins with TAPS have higher creatinine levels than recipient twins, suggesting that chronic inter-twin transfusion in TAPS may also cause short-term renal dysfunction. Long-term renal consequences in TAPS donors require further investigation.

Published
2015

4. Contents Vol. 38, 2015

Author

Masayuki Endo, Jennifer Alphonse, Luc De Catte, Jan Deprest, Mamak Shariat, Takumi Ishiodori, Ashley Wilson, Abhijit Kulkarni, Alec W. Welsh, Kiyotake Ichizuka, Wenqi Zeng, Nobuaki Mitsuda, Linda Wu, Luis Rohena, Mahdi Sheikh, Naoto Yonetani, Negar Mahmoodian, Philip DeKoninck, Satz Mengensatzproduktion, Aki Mabuchi, Kelly Gonzalez, Keisuke Ishii, Seigo Gomi, Asma Khalil, Joost Akkermans, Xiang Li, Tatsuya Arakaki, Hiroko Takita, Kenneth Glassberg, Jiancheng Guo, Masakazu Abe, Shusaku Hayashi, Neama Meriki, Heidi Rotterdam, Basky Thilaganathan, Layla Shahmirzadi, Yukiko Ban, Druckerei Stückle, Masamitsu Nakamura, Junichi Hasegawa, Shoko Hamada, Wendy K. Chung, Ashley Mills, Frans J.C.M. Klumper, Charles A. LeDuc, Junko Shiono, Antonia R. Sepulveda, Amanda Henry, Hiroshi Kawamura, Lea Tuzovic, Sha Tang, Russell Miller, Suzanne H.P. Peeters, Takashi Murakami, Kwame Anyane-Yeboa, Hitoshi Horigome, Sedigheh Hantoushzadeh, Amar Bhide, Tessa Homfray, Enrico Lopriore, Dick Oepkes, Aris T. Papageorghiou, Johanna M. Middeldorp, Akihiko Sekizawa, Sanaz Mousavi, and Aditi Mahajan

Subjects
Embryology, Pathology, medicine.medical_specialty, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, medicine, Obstetrics and Gynecology, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2015

5. Incidence of and Risk Factors for Residual Anastomoses in Twin-Twin Transfusion Syndrome Treated with Laser Surgery: A 15-Year Single-Center Experience

Author

Femke Slaghekke, Johanna M. Middeldorp, Depeng Zhao, Dick Oepkes, Monique C. Haak, J. M. M. van Klink, Patricia J.C. Knijnenburg, Enrico Lopriore, Frans J.C.M. Klumper, and Lisanne S.A. Tollenaar

Subjects
Laser surgery, Male, Embryology, medicine.medical_specialty, Multivariate analysis, Time Factors, medicine.medical_treatment, Placenta, Twin-twin transfusion syndrome, Polycythemia, Anastomosis, Single Center, Risk Assessment, Residual anastomoses, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Pregnancy, Recurrence, Risk Factors, Multifetal gestation, Diseases in Twins, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Placental Circulation, 030212 general & internal medicine, Fetoscopic laser surgery, Twin Twin Transfusion Syndrome, Monochorionic placenta, Netherlands, 030219 obstetrics & reproductive medicine, Laser Coagulation, business.industry, Incidence (epidemiology), Arteriovenous Anastomosis, Fetoscopy, Incidence, Obstetrics and Gynecology, General Medicine, Odds ratio, Fetofetal Transfusion, Solomon technique, Surgery, Treatment Outcome, Pediatrics, Perinatology and Child Health, Cohort, Female, business
Abstract

Objectives: To evaluate the incidence of residual anastomoses (RA) after laser therapy for twin-twin transfusion syndrome (TTS) and investigate risk factors for incomplete laser surgery. Material and Methods: All available TTS placentas treated with laser at our center between 2002 and 2016 were injected with color dye to assess the presence of RA. We evaluated the incidence of RA over the past 15 years by dividing the cohort into three time periods, and studied the association with risk factors and neonatal outcome. Results: Overall, RA were detected in 21.0% (78/371) of placentas. The incidence of RA decreased from 38.8% (26/67) in the initial period to 11.7% (16/137) in the most recent period (p < 0.001). On multivariate analysis, several risk factors were independently associated with the risk of RA, including Solomon laser technique (odds ratio [OR] 0.17, 95% CI 0.09–0.33) and estimation of surgical success (OR 19.28, 95% CI 8.17–45.49). Premature delivery and neonatal morbidity occurred more often in TTS cases with RA. Conclusions: The incidence of RA after laser therapy for TTS decreased significantly in the past 15 years and is now below 15% due to the use of the Solomon technique.

Published
2017

6. Contents Vol. 41, 2017

Author

Margaux F. Camus, Elie Barakat, Riccardo De Angelis, C. Azzarone, Druckerei Stückle, Eduard Gratacós, Evelyn A. Huhn, Asma Khalil, C. Migliavacca, Satz Mengensatzproduktion, Hadas Ganer Herman, Elisa Montaguti, C. Kaihura, Gianluigi Pilu, Laura Franchi, Caroline Kadji, Jacques Jani, Federica Bellussi, Núria Baños, Tullio Ghi, Irina Manokhina, Teresa Cobo, Antonio Farina, Vera Cecotti, Michal Kovo, Eleonora Mazzone, Nicola Volpe, Tanjot K. Singh, E.S. van den Akker, Eleonor Tiblad, Marije M. Kamphuis, Maren I. Müller, Vivien Dütemeyer, Elaine Sheehan, Tiziana Frusca, Antonio Percesepe, Gwendolin Manegold-Brauer, Montse Palacio, Wendy P. Robinson, Elisenda Bonet-Carne, Aly Youssef, Andrea H. Meyer, Letizia Schreiber, Maria Dolores Gómez Roig, Heidi Tiller, Sally Sabra, Hadas Miremberg, Wolfgang Holzgreve, Basky Thilaganathan, Dick Oepkes, Irene Hoesli, Sophie Bowe, Frank H. Wilhelm, Laura Triginer, Dimuthu Vinayagam, Maxime De Groof, Nicola Rizzo, Magnus Westgren, Magdalena Klass, Stefano Raboni, Stéphanie Fellas, Ginevra Salsi, Mieke Cannie, Jacob Bar, Federico Migliorelli, G. Pacella, and Alvaro Perez-Moreno

Subjects
Embryology, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2017

7. Contents Vol. 36, 2014

Author

Linda Wu, Andrew McLennan, Jennifer Sanderson, Ahm Kim, Faisal Qureshi, Irene T.M. Lindenburg, Aditi Majajan, Alkan Yildirim, Amanda Henry, Kara Juneau, Linus Bjäreborn, Suzanne M. Jacques, Magnus Nordenskjöld, Alma Aurioles-Garibay, Atıl Yüksel, Inge L. van Kamp, Satz Mengensatzproduktion, Ömer Faruk Demir, N. Scott Adzick, Roberto Romero, Patrick E. Bogard, Karin Pettersson, Mi-Young Lee, Mark P. Johnson, William H. Peranteau, Eric T. Wang, Druckerei Stückle, Gus Ridding, Sonia S. Hassan, Lemi Ibrahimoglu, Ibrahim Kalelioglu, John M.G. van Vugt, Kyu-Sang Kyeong, Harika Yumru, Nahla Khalek, Christopher Kingsley, Craig A. Struble, Annegret Geipel, Jae-Yoon Shim, Christoph Berg, Heiko Reutter, Maynor Garcia, Morassa Mohseni, Aytul Corbacioglu Esmer, Marinus A. Blankenstein, Hayri Ermiş, Tinnakorn Chaiworapongsa, Beverly G. Coleman, Jos W. R. Twisk, Paul Ryvkin, Peter Gustavsson, Lami Yeo, Alan W. Flake, Nikos Papadogiannakis, Cenk Yasa, Neama Meriki, Y. Dogan, Pil Ryang Lee, Recep Has, Ulrich Gembruch, Michael R. Mallmann, Lori J. Howell, Teresa Victoria, Hye-Sung Won, Andreas Müller, Ozlem Dural, Edgar Hernandez-Andrade, Holly L. Hedrick, Jacob Zahn, Jesse D. Vrecenak, Erik Iwarsson, Philip J. Schluter, Jon Hyett, Melanie A. J. Engels, Dick Oepkes, Hyunyoung Ahn, Stephanie Huang, Ellika Sahlin, Arnold Oliphant, Julie S. Moldenhauer, Agne Liedén, Alec W. Welsh, and Thomas M. Boemers

Subjects
Embryology, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2014

8. Hypoalbuminemia in Donors with Twin Anemia-Polycythemia Sequence

Author

Dick Oepkes, Christian V. Hulzebos, Enrico Lopriore, Femke Slaghekke, Frans J. Walther, Lianne Verbeek, Center for Liver, Digestive and Metabolic Diseases (CLDM), and Reproductive Origins of Adult Health and Disease (ROAHD)

Subjects
Male, Embryology, Placenta, PROTEIN, Twin-twin transfusion syndrome, Gastroenterology, SERUM-ALBUMIN, Hemoglobins, hemic and lymphatic diseases, Birth Weight, Twin Anemia-Polycythemia Sequence, Hypoalbuminemia, Twin Pregnancy, Netherlands, Hypoproteinemia, Academic Medical Centers, PLASMA, Obstetrics, PAIRS, Obstetrics and Gynecology, Gestational age, Anemia, Blood Proteins, Fetofetal Transfusion, General Medicine, PREGNANCY, Female, Infant, Premature, medicine.medical_specialty, FETUS, BIRTH, Gestational Age, Serum Albumin, Human, Polycythemia, Internal medicine, medicine, MANAGEMENT, Humans, Radiology, Nuclear Medicine and imaging, Serum Albumin, FETAL, Retrospective Studies, Sequence (medicine), business.industry, Infant, Newborn, Case-control study, Twin, medicine.disease, Case-Control Studies, Pediatrics, Perinatology and Child Health, Pregnancy, Twin, business
Abstract

Objective: To determine the differences in albumin levels between donors and recipients with twin anemia-polycythemia sequence (TAPS). Methods: We included all consecutive monochorionic twins with TAPS with double survivors. Each twin pair was matched for gestational age at birth with 2 control monochorionic twin pairs unaffected by TAPS or twin-twin transfusion syndrome. We measured levels of albumin, total protein, and hemoglobin on the first day of life in donors and recipients (TAPS group) and the control group. Results: A total of 25 TAPS twin pairs and 50 control twin pairs were included in the study. The median gestational age at birth was 32 weeks in both groups. In the TAPS group, median levels (IQR) of albumin in donor twins were significantly lower than in recipient twins, i.e. 28.0 g/l (24.0-32.0) versus 32.0 g/l (30.0-34.5) (p = 0.008). Median levels (IQR) of total protein in donor twins were also lower than in recipients, i.e. 44.0 g/l (36.5-49.0) versus 49.0 g/l (46.5-51.0), respectively (p = 0.004). The median (IQR) intertwin albumin difference was significantly higher in the TAPS group than in the control group, i.e. 4.0 g/l (2.5-10.5) versus 2.0 g/l (1.0-4.0) (p = 0.003). The rate of hypoalbuminemia (Conclusions: In addition to lower hemoglobin levels, donor twins with TAPS also have significantly lower albumin and total protein levels compared to recipient twins.

Published
2013

9. Contents Vol. 29, 2011

Author

L. Mobili, Druck Reinhardt Druck Basel, Ji Young Huh, David Pauzner, Keiji Tatsumi, Yoshiki Mikami, Harold Stanislaw, Munekazu Komada, Myung Seo Kang, C. Giorlandino, A. Zaccara, Joseph B. Lessing, Ignacio Herraiz, C. Brizzi, Irene T.M. Lindenburg, Jin Hee Kang, Gerard G. Nahum, Juan Balasch, Rohan Lourie, Frans J.C.M. Klumper, Hiroshi Fujiwara, Ishai Levin, Alberto Galindo, Surabhi Nanda, Debra J. Wolgemuth, Glenn Gardener, Geoff Daniels, M. De Gennaro, A. Nahom, Dick Oepkes, Sang Hee Jung, Yukiko Izumi, Ikuo Konishi, Won Bo Hahn, Ramesh Kuppusamy, Danielle Sodre, Katsura Minegishi, Avital Skornick Rapaport, Sung Woon Chang, Stephen Cattanach, Kazuyo Kakui, Inge L. van Kamp, Dong Hyun Cha, David Lora, Kypros H. Nicolaides, Ranjit Akolekar, Satz Mengensatzproduktion, A. Marciano, Yukiyasu Sato, Frank P.H.A. Vandenbussche, Laxmi V. Baxi, Joseph T. Thomas, Vladimir Buchman, Xiangyuan Wang, Shigehito Yamada, Kirstin Finning, Juan Carlos Melchor, D. Escribano, Ronni Gamzu, Scott Petersen, Park Hea Ree, M. Hoopmann, Benny Almog, E. Carnevale, Adriana Olog, K.O. Kagan, Ron Wolterbeek, Eirini Vaikousi, Eduard Gratacós, and Javier de la Cruz

Subjects
Embryology, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2011

10. Total Blood Volume Is Maintained in Nonhydropic Fetuses with Severe Hemolytic Anemia

Author

C. P. Bil van den Brink, Frank P.H.A. Vandenbussche, P. N. Adama van Scheltema, M. A. Kamping, Dick Oepkes, and S.A. Pasman

Subjects
Hemolytic anemia, Embryology, medicine.medical_specialty, Anemia, Hydrops Fetalis, Blood Transfusion, Intrauterine, Gestational Age, Blood volume, macromolecular substances, Anemia, Hemolytic, Congenital, Fetus, Prenatal Diagnosis, Hydrops fetalis, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Neonatology, Blood Volume, business.industry, fungi, food and beverages, Obstetrics and Gynecology, General Medicine, medicine.disease, Surgery, Red blood cell, medicine.anatomical_structure, In utero, Pediatrics, Perinatology and Child Health, Cardiology, business
Abstract

Objective: Fetal alloimmune anemia is associated with increased blood flow velocities and cardiomegaly. In severe cases, hydrops can develop. We investigated whether the decrease of red blood cell volume is associated with a reduction or expansion of plasma volume. Methods: In 86 alloimmunized fetuses that received a first intrauterine transfusion, we calculated fetal total blood volumes (i.e. fetoplacental blood volumes) using a dilutional principle of fetal hemoglobin with adult hemoglobin. The relation between total blood volume and estimated fetal weight, severity of anemia and hydrops was analyzed. Results: Gestational age ranged from 17 to 35 weeks. Mean hemoglobin deficit was 6.8 standard deviations (range 2.1–11.7) below the normal mean. Fetal total blood volume was significantly related to estimated fetal weight (p < 0.001). Mean total blood volume in nonhydropic fetuses was 123 ml/kg (n = 74) and in hydropic fetuses 144 ml/kg (n = 12). There was a significant relation between total blood volume per kg body weight and hydrops (p = 0.035); however, there was no relation with severity of anemia (p = 0.94). Conclusion: In the human nonhydropic fetus with severe hemolytic anemia, total blood volume is maintained: the decrease in red blood cell volume is thus compensated by an increase in plasma volume. In hydropic fetuses, however, total blood volume seems to be increased. This is in accordance with the hypothesis that congestive heart failure plays a role in the pathophysiology of hydrops in anemic fetuses.

Published
2009

11. Contents Vol. 24, 2008

Author

Timo R. de Haan, Akio Ishiguro, Shiro Kohzuma, Tamme Goecker, P. Papasozomenou, Lourens R. Pistorius, Masaru Takamizawa, F. Fascetti Leon, Jong Chul Shin, Tanja Wolf, Vajih Marsusy, Akihide Ohkuchi, Kimiyo Takagi, Hiroo Naruse, Mei-Leng Joy Cheong, Akio Izumi, Taisto Sarkola, L. Pasquini, Yung Hang Lam, Umur Kuyumcuoğlu, Alexandra Benachi, Hideaki Sawai, Sandra L. Marles, P. Midrio, Marcelo Zugaib, Mark P. Johnson, Jaime Smal, A.P. Athanasiadis, R. Bouvier, Keisuke Ishii, Ken Miyazaki, Peter van Leeuwen, Florent Fuchs, Gregory J. Reid, J. M. Levaillant, L. Michel-Calemard, Takashi Watanabe, Dick Oepkes, Lorna Spagnol, Mary Hoi Yin Tang, Saori Nakahara, Yves Dumez, Sedighh Hantushzadeh, Naime Canoruç, Yutaka Kanamori, Vito Briganti, Alessandro Calisti, Simonetta Costa, C. Arnaoutoglou, Onder Sahin, L. Florentin-Arar, Mitsuru Matsushita, Asuka Kiyota, Raul A. Cortes, Luc Gourand, Alpay Haktanır, Ali İrfan Güzel, Kana Yoshida, Giovanni Mangia, Richard S. Finkel, R. Douglas Wilson, Pil Ryang Lee, A Ramoni, Christoph Brezinka, Jose Antonio de Azevedo Magalhães, Ahmet Kale, Kaoru Ishikawa, Ebru Kale, Marianne Eronen, Immacolata Savarese, Gustavo Lobato, M. V. Senat, Dietrich Grönemeyer, Eduard Kucera, Georgia Kokkali, Yuki Iwasawa, Hiroji Minami, Birgitta Hagnefelt, Juha-Matti Happonen, In Yang Park, Hye-Sung Won, Kyousuke Takeuchi, Nina R. Stein, Maria Mercedes C. Fonseca, Wolfgang Hatzmann, Fatemeh Rahimi Sharbaf, Fatemeh Davari, Véronique Mirlesse, Hirohisa Kurachi, Bruno Barthe, Godelieve C.M.L. Page-Christiaens, Cristina Silveira Soncini, Talvikki Boldt, Jaroslav Feyereisl, Stefanie Kasperski, Fatemeh Baradaran, Alina Solopova, Josef Wisser, Riitta Karikoski, Pascale Sonigo, Olivier Picone, Yasushi Takahata, Maurizio Pacilli, Christopher Konialis, Ralf L. Schild, Marie I. Hadfield, P. Polychronou, Joscha Reinhard, Kojiro Minami, Alexander Alge, Ming-Song Tsai, Francesco Morini, Sven Schiermeier, Matthias W. Beckmann, Denis A. Cozzi, Hiroshi Kawame, Hironobu Hyodo, Adem Aslan, Masahiko Sugiyama, Satoshi Hojo, A.E. Mas, Konstantinos Pantos, Carmela Votino, Fujimi Arai, Lee Young, Seiichi Morokuma, Lucia Oriolo, Min Chen, Yasuo Yumoto, Hiroshi Kawashima, P.G. Gamba, Keiji Goishi, Denise Schlatter, Nicola Hart, Heeyoung Lee, Hideki Nakayama, Kyoko Ono, Shigeki Matsubara, Takako Ohmaru, Yuichi Torii, Jae-Yoon Shim, Zahra Elahipanah, Gen Nishimura, Marie-Cécile Aubry, Kotaro Fukushima, Kayo Takahashi, Alessandra Fritsch, J.N. Bontis, Shun-ichi Yamaguchi, Françoise Parnet-Mathieu, Madoka Furuhashi, Jan Evangelista Jirasek, Elizabeth Lau, F. Dijoud, Bettina Bessières, Francesco Cozzi, Takeshi Maruo, Takashi Igarashi, Jeffrey A. Golden, M. Zafrakas, P. Roth, Albert E. Chudley, Lucy Ng, S. Kumar, G. Blin, Philippe Molle, Shinya Tsuchida, Josef Hager, Mitsuaki Suzuki, Tomohiko Nakamura, Jörn Siemer, Hui-Zhu Zhong, Seiji Tsutsumi, Jane E. Corteville, Laurent Mandelbrot, M. Mabille, Yoshimasa Kamei, Rodrigo Ruano, Michael R. Harrison, Bernard N. Chodirker, Tadashi Iwanaka, G. Norbury, Daniele De Luca, Marcos Nakamura-Pereira, A. Tregnaghi, Christian Marth, Akihiko Kikuchi, Nanae Oda, M.L. Moutard, Keiko Miyachi Takikawa, Gernot Reiter, Can Liao, Caroline B. Maurmann, Kiyomi Tsukimori, Kiyoshi Hayasaka, R.C. Rudigoz, P. Arnould, R. Abel, Sorahiro Sunagawa, Makoto Komura, Ari Kim, Norio Wake, Matthias Scheier, Costantino Romagnoli, Ayumi Tanaka, Tomoyuki Kuwata, Mehmet Yilmazer, Rie Usui, Akiko Yokoyama, Chin Peng Lee, Dong-Zhi Li, Allison M. Brennan, Jian Li, Gülengül Köken, Takeshi Murakoshi, D. Combourieu, Jérôme Massardier, Alison Rusnak, Takashi Sinno, Figen Kir Sahin, Britta Meurer, Ahm Kim, Maria Pia De Carolis, D. Gobbi, Malgorzata A. Verboon-Maciolek, Robert Dankovcik, Emine Coşar, P. Gaucherand, Jozef Radonak, Consolato Sergi, Narges Izadi Mood, Elisa Macedo Brietzke, Constantinos G. Pangalos, Michael Schrauder, Linda S. de Vries, Thierry A.G.M. Huisman, K. Lüthgens, Yuji Taketani, René Frydman, Ricardo Palma-Dias, Marek Dudas, and Fernand Daffos

Subjects
Embryology, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2008

12. Laparoscopically Guided Uterine Entry for Fetoscopy in Twin-to-Twin Transfusion Syndrome with Completely Anterior Placenta: A Novel Technique

Author

Frank P.H.A. Vandenbussche, Enrico Lopriore, Marieke Sueters, Johanna M. Middeldorp, Frans J.C.M. Klumper, Frank W. Jansen, Dick Oepkes, and Jan Ringers

Subjects
Embryology, medicine.medical_specialty, medicine.medical_treatment, Uterus, macromolecular substances, Anastomosis, Twin-to-twin transfusion syndrome, Fetoscopy, Pregnancy, Placenta, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Prospective Studies, Laparoscopy, Ultrasonography, Gynecology, medicine.diagnostic_test, business.industry, Infant, Newborn, Obstetrics and Gynecology, Fetofetal Transfusion, General Medicine, medicine.disease, Endoscopy, Surgery, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Female, business, Laser coagulation
Abstract

Objective: Laser coagulationof anastomotic vessels on the placental surface is the treatment of choice in severe second trimester twin-to-twin transfusion syndrome (TTTS). This procedure is associated with technical difficulties when the placenta is located on the anterior side of the uterus. We describe a novel technique for fetoscopy in TTTS with completely anterior placenta where laparoscopy is used to guide safe percutaneous insertion of the fetoscope through the lateral abdominal wall and the dorsal side of the uterus. Methods: Prospective controlled series of 16 TTTS pregnancies with completely anterior placenta (study group) treated with this novel technique. Studied outcomes were technical result of the procedure and perinatal survival. Outcome in the study group was compared with outcome of 49 TTTS pregnancies treated with conventional percutaneous fetoscopic laser without laparoscopy, 9 of these with partially anterior placenta (control group A) and 40 with lateral or posterior placenta (control group B). Results: In the study group, the procedure-related complication rate was 25% (4/16). In 1 case, uterine entry of the fetoscope from the lateral abdominal wall was not possible due to complex bowel adhesions. In 3 patients, intra-amniotic haemorrhage occurred after fetoscopic entry, preventing complete laser coagulation of anastomoses. One of these patients required 2 units of blood transfusion. The procedure-related complication rate in control groups A and B was 22% (2/9) and 5% (2/40), respectively (intra-amniotic haemorrhage n = 3, severe leakage of amniotic fluid into the peritoneal cavity, n = 1). Perinatal survival in the study group, control group A and control group B was 63% (20/32), 78% (14/18) and 70% (56/80), respectively. Conclusion: Combined laparoscopy and fetoscopy is a novel technique that enables safe uterine entry and creates optimal visualisation for laser coagulation of inter-twin anastomoses in TTTS pregnancies with completely anterior placenta. The procedure-related complication rate and perinatal survival rate were similar compared to the conventional percutaneous technique. Procedure-related complications occur more often with partially or completely anterior placenta.

Published
2007

13. Parvovirus B19 infection in pregnancy studied by maternal viral load and immune responses

Author

Timo R. de Haan, Frans J. Walther, Matthias F. C. Beersma, Aloys C.M. Kroes, Dick Oepkes, Eric C. J. Claas, Amsterdam Neuroscience, Other Research, and Neonatology

Subjects
Adult, Embryology, viruses, Virus, Parvoviridae Infections, Immune system, Pregnancy, hemic and lymphatic diseases, Parvovirus B19, Human, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Pregnancy Complications, Infectious, Parvoviridae, Fetus, biology, business.industry, Parvovirus, virus diseases, Obstetrics and Gynecology, General Medicine, Viral Load, Fetal Blood, biology.organism_classification, medicine.disease, Infectious Disease Transmission, Vertical, Immunoglobulin M, Immunoglobulin G, DNA, Viral, Pediatrics, Perinatology and Child Health, Immunology, biology.protein, Female, Antibody, business, Viral load
Abstract

Objectives: Facilitate risk assessment of vital complications in fetuses of pregnancies affected by acute parvovirus B19 (B19V) infection. Design: Study of the natural course of maternal B19V infection in four cases, from early pregnancy on. Setting: University Medical Center in the Netherlands. Population: Pregnant mothers attending obstetric services. Methods: Serial measurements of the maternal and fetal or neonatal viral load and antibody responses. Main Outcome Measures: Maternal and fetal/neonatal serum B19V viral DNA load and specific IgM and IgG antibodies in maternal serum. Results: Peak viral load levels occurred within 1 week after maternal infection and peak IgM levels were observed 1 week after the peak viral load levels. Approximation of IgG and IgM ratios usually took place 4 weeks after infection. Vertical transmission occurred 1–3 weeks after maternal infection, suggesting that fetal infection occurs during the maternal peak viral load. Conclusions: Maternal B19V DNA load levels and IgM responses are useful to estimate the risk of parvovirus B19-associated fetal complications. The maternal peak viral load directly precedes the onset of fetal infection and may be used to indicate the stage of intrauterine B19V infection.

Published
2007

14. Contents Vol. 37, 2015

Author

Enrico Lopriore, Greg Kesby, Athena P. Souka, Ioannis Papastefanou, Joan Rodo, Po Jen Cheng, Andrew McLennan, Yin Jiun Tseng, S.W. Steven Shaw, Athanasios Pilalis, Joost Akkermans, Ioannis Kavalakis, Gus Ridding, Olga Leticia Fuchs Gómez, Rabih Chaoui, Arlyn Llanes, Woei-Chyn Chu, Jon Hyett, Satz Mengensatzproduktion, Eftichia V. Kontopoulos, Nicola Rizzo, Dimitrios Kassanos, Magdalena Sanz-Cortes, Eduard Gratacós, Sammya Bezerra Maia, Ramen H. Chmait, Federica Bellussi, Paulo Cesar Praciano de Sousa, Lisa M. Korst, S. Savchev, Elena Contro, Frans J.C.M. Klumper, Ran Chou Chen, K. Karl, G. Egaña-Ugrinovic, Wellington P. Martins, Robert Ogle, Dick Oepkes, Druckerei Stückle, Júlio Augusto Gurgel Alves, Fabricio da Silva Costa, Letizia Conti, Dimitra Kappou, Carolina Bazán-Arcos, Federica Martelli, Brooke O'Brien, Bienvenido Puerto, Philip J. Schluter, Ingrid Rieger, Gianluigi Pilu, Esther Passchyn, Guido Cocchi, Tullio Ghi, A. H. Miyague, Johanna M. Middeldorp, Aly Youssef, Narcís Masoller, Roland Devlieger, Jan Deprest, José María Martínez, Ching Hua Hsiao, K.-S. Heling, Suzanne H.P. Peeters, Kristi R. Van Winden, Roberto Conturso, Rubén A. Quintero, and G. Pacella

Subjects
Embryology, Pathology, medicine.medical_specialty, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, medicine, Obstetrics and Gynecology, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2015

15. Immunoglobulins in Neonates with Rhesus Hemolytic Disease of the Fetus and Newborn: Long-Term Outcome in a Randomized Trial

Author

Jeanine M.M. van Klink, Dick Oepkes, Suzanne J van Veen, Monique Rijken, Vivianne E.H.J. Smits-Wintjens, Enrico Lopriore, and Irene T.M. Lindenburg

Subjects
Embryology, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Exchange Transfusion, Whole Blood, Exchange transfusion, Long Term Adverse Effects, 030204 cardiovascular system & hematology, Placebo, Rh Isoimmunization, law.invention, Cerebral palsy, Erythroblastosis, Fetal, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, 030225 pediatrics, medicine, Humans, Radiology, Nuclear Medicine and imaging, Intravenous immunoglobulin, Intelligence Tests, Fetus, Intelligence quotient, business.industry, Incidence (epidemiology), Immunization, Passive, Infant, Newborn, Obstetrics and Gynecology, Immunoglobulins, Intravenous, General Medicine, medicine.disease, Otorhinolaryngologic Diseases, Treatment Outcome, Neurodevelopmental Disorders, Child, Preschool, Rhesus hemolytic disease of the fetus and newborn, Pediatrics, Perinatology and Child Health, business, Follow-Up Studies
Abstract

Objective: Prophylactic intravenous immunoglobulin (IVIg) does neither reduce the need for exchange transfusion nor the rates of other adverse neonatal outcomes in neonates with rhesus hemolytic disease of the fetus and newborn (rhesus HDFN) according to our randomized controlled trial analysis. Our objective was to assess the long-term neurodevelopmental outcome in the children included in the trial and treated with either IVIg or placebo. Methods: All families of the children included in the trial were asked to participate in this follow-up study. The long-term neurodevelopmental outcome in children at least 2 years of age was assessed using standardized tests. The primary outcome was the incidence of neurodevelopmental impairment defined as at least one of the following: cerebral palsy, severe cognitive and/or motor developmental delay (with a test score of less than -2 SD), bilateral deafness or blindness. Results: Sixty-six of the 80 children (82.5%) who had been recruited to the initial randomized controlled trial participated in the follow-up study. The children were assessed at a median age of 4 years (range 2-7). The median cognitive score was 96 (range 68-118) in the IVIg group and 97 (range 66-118) in the placebo group (p = 0.79). There was no difference in the rate of neurodevelopmental impairment between the IVIg and the placebo group [3% (1/34) vs. 3% (1/32); p = 1.00]. Conclusions: The long-term neurodevelopmental outcome in children treated with IVIg was not different from that in children treated with placebo. Standardized long-term follow-up studies with large enough case series and sufficient power are needed to replicate these findings.

Published
2015

16. Effect of an Increase of the Hematocrit on Middle Cerebral Artery Peak and Umbilical Vein Maximum Velocities in Anemic Fetuses

Author

Frank P.H.A. Vandenbussche, Dick Oepkes, Esther Sikkel, Robertjan H. Meerman, Katinka A.K. Teunissen, Humphrey H.H. Kanhai, Saskia le Cessie, and Frans J.C.M. Klumper

Subjects
Middle Cerebral Artery, Umbilical Veins, Embryology, Blood transfusion, medicine.medical_treatment, Blood Transfusion, Intrauterine, Hemodynamics, Hematocrit, Umbilical vein, Pregnancy, medicine.artery, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Analysis of Variance, Fetus, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Anemia, Ultrasonography, Doppler, General Medicine, Blood flow, Fetal Diseases, Anesthesia, Pediatrics, Perinatology and Child Health, Circulatory system, Middle cerebral artery, Female, business, Blood Flow Velocity
Abstract

Objective: To measure the effects of acute large increases of the hematocrit on fetal peak arterial and maximum venous blood flow velocities. Methods: Middle cerebral artery peak flow velocities and umbilical vein maximum flow velocities were measured before, immediately after, and 12–24 h after intrauterine transfusions. All measurements were standardized for gestational age. Results: Complete measurements were obtained at 60 intrauterine transfusions. The mean hematocrit before intrauterine transfusion was 0.19 l/l and after 0.40 l/l. The middle cerebral artery peak flow velocity decreased immediately after transfusion in 59 of the 60 cases. There was a rise in umbilical vein maximum flow velocity immediately after intrauterine transfusion in 37 of the 60 cases. The sensitivity of middle cerebral artery peak flow velocity for severe anemia before intrauterine transfusion was 54% and the specificity 57%. The sensitivity of umbilical vein maximum flow velocity for severe anemia before intrauterine transfusion was 67% and the specificity 57%. Conclusions: An acute large increase of the fetal hematocrit significantly decreases middle cerebral artery peak flow velocity. The effect on umbilical vein maximum velocity is, however, unpredictable.

Published
2003

17. Low-Dose versus Standard-Dose Intravenous Immunoglobulin to Prevent Fetal Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia: A Randomized Trial

Author

Eline S.A. Van Den Akker, Noortje P. Paridaans, Marije M. Kamphuis, Magnus Westgren, Agneta Wikman, Dick Oepkes, Daniel Challis, Enrico Lopriore, and Eleonor Tiblad

Subjects
Adult, Embryology, medicine.medical_specialty, Internationality, Noninvasive treatment, Intracranial hemorrhage, Gastroenterology, law.invention, Young Adult, Randomized controlled trial, law, Pregnancy, Internal medicine, Multicenter trial, medicine, Humans, Radiology, Nuclear Medicine and imaging, Young adult, Intravenous immunoglobulin, Fetus, Fetal neonatal alloimmune thrombocytopenia, Intention-to-treat analysis, biology, business.industry, Infant, Newborn, Obstetrics and Gynecology, Immunoglobulins, Intravenous, General Medicine, medicine.disease, Human platelet antigen, Thrombocytopenia, Neonatal Alloimmune, Fetal therapy, Fetal Diseases, Anesthesia, Pediatrics, Perinatology and Child Health, Neonatal alloimmune thrombocytopenia, biology.protein, Female, business, Intracranial Hemorrhages
Abstract

Objective: Pregnancies at risk of fetal and neonatal alloimmune thrombocytopenia (FNAIT) are commonly treated using weekly intravenous immunoglobulin (IVIG) at 1 g/kg maternal weight. IVIG is an expensive multidonor human blood product with dose-related side effects. Our aim was to evaluate the effectiveness of IVIG at a lower dose, i.e. 0.5 g/kg. Methods: This was a randomized controlled multicenter trial conducted in Sweden, the Netherlands and Australia. Pregnant women with human platelet antigen alloantibodies and an affected previous child without intracranial hemorrhage (ICH) were enrolled. The participants were randomized to IVIG at 0.5 or 1 g/kg per week. The analyses were per intention to treat. The primary outcome was fetal or neonatal ICH. Secondary outcomes were platelet count at birth, maternal and neonatal IgG levels, neonatal treatment and bleeding other than ICH. Results: A total of 23 women were randomized into two groups (low dose: n = 12; standard dose: n = 11). The trial was stopped early due to poor recruitment. No ICH occurred. The median newborn platelet count was 81 × 109/l (range 8-269) in the 0.5 g/kg group versus 110 × 109/l (range 11-279) in the 1 g/kg group (p = 0.644). Conclusion: The risk of adverse outcomes in FNAIT pregnancies treated with IVIG at 0.5 g/kg is very low, similar to that using 1 g/kg, although our uncompleted trial lacked the power to conclusively prove the noninferiority of using the low dose.

Published
2014

18. Fetal Brain Hemodynamic Changes in Intrauterine Transfusion: Influence of Needle Puncture Site

Author

Esther Sikkel, Frank P.H.A. Vandenbussche, P. N. Adama van Scheltema, S. Borkent, and Dick Oepkes

Subjects
Embryology, medicine.medical_specialty, Blood transfusion, medicine.medical_treatment, Blood Transfusion, Intrauterine, Hemodynamics, Blood volume, Punctures, Pregnancy, Stress, Physiological, Laser-Doppler Flowmetry, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Neonatology, skin and connective tissue diseases, Vein, Fetus, Blood Volume, business.industry, Brain, Obstetrics and Gynecology, Anemia, General Medicine, Fetal Diseases, medicine.anatomical_structure, In utero, Anesthesia, Pediatrics, Perinatology and Child Health, Gestation, Female, sense organs, business
Abstract

Objectives: Previous research has suggested that hemodynamic changes after in utero transfusion may be related to fetal stress. We tested the hypothesis that these hemodynamic changes are more pronounced when the needle is inserted in the fetal abdomen compared with the umbilical cord root. Methods: Most intrauterine transfusions are performed by inserting a needle either in the umbilical cord root at the placental surface (PCI) or in the intrahepatic portion of the umbilical vein (IHV). We analyzed prospectively collected data of all intrauterine blood transfusions (IUT) for fetal alloimmune anemia (from 2000 to 2003), for which complete data were available on needling site and middle cerebral artery (MCA) Doppler flow velocity measurements before and immediately after the procedure. Results: Data of 57 IUTs were included. In 32 patients, the transfusion was performed through the PCI and in 25 patients through the IHV. Mean pulsatility index (PI) in the PCI group was 2.0 before and 1.7 after IUT (p = 0.011), and in the IHV group 1.9 before and 1.5 after IUT (p = 0.001). In both groups, MCA PI decreased significantly, but there was no difference in decrease between the two groups (p = 0.99). Conclusions: In anemic fetuses undergoing transfusion, the observed fetal brain hemodynamic changes were independent of the site of needle insertion. The decrease in fetal MCA PI is therefore likely to be caused by the volume expansion.

Published
2009

19. Subject Index Vol. 24, 2008

Author

Godelieve C.M.L. Page-Christiaens, Cristina Silveira Soncini, Takashi Sinno, Figen Kir Sahin, Yasuo Yumoto, Jae-Yoon Shim, Jörn Siemer, Hui-Zhu Zhong, M. Mabille, Alpay Haktanir, Francesco Cozzi, Takeshi Maruo, Jeffrey A. Golden, Maria Pia De Carolis, D. Gobbi, Malgorzata A. Verboon-Maciolek, F. Dijoud, Denise Schlatter, Nicola Hart, Linda S. de Vries, Marianne Eronen, Riitta Karikoski, Dietrich Grönemeyer, Takako Ohmaru, Thierry A.G.M. Huisman, Lucia Oriolo, Shiro Kohzuma, K. Lüthgens, Kotaro Fukushima, Juha-Matti Happonen, In Yang Park, M. V. Senat, Hye-Sung Won, Eduard Kucera, Akihide Ohkuchi, Hirohisa Kurachi, Fatemeh Davari, R. Abel, Wolfgang Hatzmann, Ahmet Kale, Jong Chul Shin, Akio Izumi, Kojiro Minami, Denis A. Cozzi, Laurent Mandelbrot, Hironobu Hyodo, Immacolata Savarese, Gustavo Lobato, P. Papasozomenou, P. Gaucherand, Taisto Sarkola, A.E. Mas, Konstantinos Pantos, Vajih Marsusy, Fujimi Arai, Yuji Taketani, Peter van Leeuwen, Heeyoung Lee, Hideki Nakayama, P.G. Gamba, Hideaki Sawai, Marie-Cécile Aubry, Adem Aslan, Lorna Spagnol, Talvikki Boldt, Elizabeth Lau, René Frydman, Yutaka Kanamori, Daniele De Luca, Marcos Nakamura-Pereira, Jozef Radonak, Jan Evangelista Jirasek, Bettina Bessières, Dick Oepkes, Consolato Sergi, Tamme Goecker, Narges Izadi Mood, Vito Briganti, Ken Miyazaki, Can Liao, Madoka Furuhashi, Ari Kim, A Ramoni, Shigeki Matsubara, Takashi Watanabe, Norio Wake, Michael R. Harrison, Bernard N. Chodirker, Shinya Tsuchida, Alessandra Fritsch, J.N. Bontis, G. Norbury, Timo R. de Haan, Akio Ishiguro, L. Michel-Calemard, S. Kumar, Tadashi Iwanaka, Elisa Macedo Brietzke, Bruno Barthe, Richard S. Finkel, R. Douglas Wilson, Matthias W. Beckmann, Ricardo Palma-Dias, Naime Canoruç, Luc Gourand, A. Tregnaghi, Mary Hoi Yin Tang, Constantinos G. Pangalos, Seiji Tsutsumi, Michael Schrauder, Alexander Alge, Jane E. Corteville, Pil Ryang Lee, Marek Dudas, Lourens R. Pistorius, Ali İrfan Güzel, Yuichi Torii, Carmela Votino, Emine Coşar, Ming-Song Tsai, Gernot Reiter, Fatemeh Baradaran, Masaru Takamizawa, Yuki Iwasawa, Hiroji Minami, Kiyomi Tsukimori, Olivier Picone, Alina Solopova, Josef Wisser, Christian Marth, P. Arnould, Matthias Scheier, Pascale Sonigo, Takashi Igarashi, Costantino Romagnoli, P. Polychronou, Nina R. Stein, Maria Mercedes C. Fonseca, Joscha Reinhard, Kimiyo Takagi, Mei-Leng Joy Cheong, F. Fascetti Leon, Francesco Morini, Birgitta Hagnefelt, Véronique Mirlesse, Fernand Daffos, Kyousuke Takeuchi, M.L. Moutard, Keiko Miyachi Takikawa, Fatemeh Rahimi Sharbaf, Hiroshi Kawame, G. Blin, Rodrigo Ruano, Makoto Komura, Caroline B. Maurmann, Kiyoshi Hayasaka, Hiroshi Kawashima, Alexandra Benachi, Hiroo Naruse, M. Zafrakas, Alessandro Calisti, L. Pasquini, Simonetta Costa, C. Arnaoutoglou, Giovanni Mangia, Masahiko Sugiyama, Zahra Elahipanah, Satoshi Hojo, Ebru Kale, Lucy Ng, P. Roth, Albert E. Chudley, Philippe Molle, Gen Nishimura, Sedighh Hantushzadeh, Tomoyuki Kuwata, Akihiko Kikuchi, Umur Kuyumcuoğlu, Françoise Parnet-Mathieu, Mehmet Yilmazer, Saori Nakahara, Tomohiko Nakamura, Yves Dumez, R.C. Rudigoz, Kana Yoshida, Sorahiro Sunagawa, Sandra L. Marles, Marcelo Zugaib, Mark P. Johnson, Jaime Smal, A.P. Athanasiadis, R. Bouvier, Florent Fuchs, Gregory J. Reid, Nanae Oda, Akiko Yokoyama, Tanja Wolf, Chin Peng Lee, Yung Hang Lam, P. Midrio, Jose Antonio de Azevedo Magalhães, L. Florentin-Arar, Marie I. Hadfield, Keisuke Ishii, Lee Young, Seiichi Morokuma, Min Chen, Keiji Goishi, Josef Hager, Mitsuaki Suzuki, D. Combourieu, Mitsuru Matsushita, Kayo Takahashi, Shun-ichi Yamaguchi, Kaoru Ishikawa, Yasushi Takahata, Maurizio Pacilli, Ayumi Tanaka, Christopher Konialis, Rie Usui, Sven Schiermeier, Britta Meurer, Kyoko Ono, Ahm Kim, Georgia Kokkali, Jaroslav Feyereisl, Stefanie Kasperski, Ralf L. Schild, Robert Dankovcik, Onder Sahin, Asuka Kiyota, Raul A. Cortes, Christoph Brezinka, Yoshimasa Kamei, Dong-Zhi Li, Allison M. Brennan, Jian Li, Gülengül Köken, Takeshi Murakoshi, Jérôme Massardier, Alison Rusnak, and J. M. Levaillant

Subjects
Embryology, Index (economics), business.industry, Pediatrics, Perinatology and Child Health, Statistics, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, Subject (documents), General Medicine, business
Published
2008

20. Twin anemia-polycythemia sequence: diagnostic criteria, classification, perinatal management and outcome

Author

Femke Slaghekke, Frans J.C.M. Klumper, Enrico Lopriore, W. J. Kist, Frank P.H.A. Vandenbussche, Frans J. Walther, Dick Oepkes, Johanna M. Middeldorp, and S.A. Pasman

Subjects
Embryology, medicine.medical_specialty, Pediatrics, Amniotic fluid, Anemia, Placenta, Polycythemia, Anastomosis, Pregnancy, Prenatal Diagnosis, medicine, Twin Anemia-Polycythemia Sequence, Humans, Radiology, Nuclear Medicine and imaging, Neonatology, Sequence (medicine), Fetus, Cardiovascular diseases [NCEBP 14], business.industry, Incidence, Obstetrics and Gynecology, General Medicine, Fetofetal Transfusion, medicine.disease, Twin anemia-polycythemia sequence Twin-twin transfusion syndrome Oligopolyhydramnios sequence oligo-polyhydramnios sequence chorionic-plate-anastomoses transfusion-syndrome monochorionic twins laser coagulation gestation complications therapy, Fetal Diseases, Treatment Outcome, Pediatrics, Perinatology and Child Health, Female, Monochorionic twins, business
Abstract

Monochorionic twins share a single placenta with intertwin vascular anastomoses, allowing the transfer of blood from one fetus to the other and vice versa. These anastomoses are the essential anatomical substrate for the development of several complications, including twin-twin transfusion syndrome (TTTS) and twin anemia-polycythemia sequence (TAPS). TTTS and TAPS are both chronic forms of fetofetal transfusion. TTTS is characterized by the twin oligopolyhydramnios sequence, whereas TAPS is characterized by large intertwin hemoglobin differences in the absence of amniotic fluid discordances. TAPS may occur spontaneously in up to 5% of monochorionic twins and may also develop after incomplete laser treatment in TTTS cases. This review focuses on the pathogenesis, incidence, diagnostic criteria, management options and outcome in TAPS. In addition, we propose a classification system for antenatal and postnatal TAPS. Copyright (C) 2010 S. Karger AG, Basel

Published
2010

21. Disturbance of cerebral neuronal migration following congenital parvovirus B19 infection

Author

Timo R. de Haan, Godelieve C.M.L. Page-Christiaens, Jaime Smal, Lourens R. Pistorius, Linda S. de Vries, Malgorzata A. Verboon-Maciolek, Dick Oepkes, ANS - Amsterdam Neuroscience, Other Research, and Neonatology

Subjects
Adult, Embryology, Pathology, medicine.medical_specialty, Blood transfusion, medicine.medical_treatment, viruses, Hydrops Fetalis, Neuronal migration, Blood Transfusion, Intrauterine, macromolecular substances, Choristoma, Ultrasonography, Prenatal, Parvoviridae Infections, Cell Movement, Pregnancy, hemic and lymphatic diseases, medicine, Parvovirus B19, Human, Humans, Radiology, Nuclear Medicine and imaging, Encephalitis, Viral, Brain Diseases, medicine.diagnostic_test, biology, Parvovirus, business.industry, Clinical course, Infant, Newborn, Obstetrics and Gynecology, virus diseases, Brain, Magnetic resonance imaging, General Medicine, medicine.disease, biology.organism_classification, Magnetic Resonance Imaging, embryonic structures, Pediatrics, Perinatology and Child Health, Gestation, Female, business, Encephalitis
Abstract

Objective: We describe the clinical course of an infant who presented with severe fetal anemia and fetal hydrops following congenital parvovirus B19 infection before 16 gestational weeks. The fetus was treated by cordocentesis and intrauterine transfusion at 18 weeks. Results: The infant demonstrated mild unilateral ventriculomegaly on antenatal magnetic resonance imaging, and polymicrogyria and heterotopia on postnatal magnetic resonance imaging. Conclusion: This adds to the evidence in recent literature of central nervous system damage associated with congenital parvovirus B19 infection.

Published
2007

22. Fetoscopic laser surgery in 100 pregnancies with severe twin-to-twin transfusion syndrome in the Netherlands

Author

Johanna M. Middeldorp, Marieke Sueters, Enrico Lopriore, Frans J.C.M. Klumper, Frank P.H.A. Vandenbussche, Roland Devlieger, Dick Oepkes, and Humphrey H.H. Kanhai

Subjects
Laser surgery, Embryology, medicine.medical_specialty, medicine.medical_treatment, Prenatal diagnosis, Gestational Age, Twin-to-twin transfusion syndrome, Second trimester, Pregnancy, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective cohort study, Twin Pregnancy, Netherlands, Fetal Therapies, business.industry, Obstetrics, Fetoscopy, Infant, Newborn, Obstetrics and Gynecology, Gestational age, General Medicine, Fetofetal Transfusion, medicine.disease, Surgery, Treatment Outcome, Pediatrics, Perinatology and Child Health, Female, Laser Therapy, business
Abstract

Objective: In this prospective cohort study, we evaluated the initial results of fetoscopic laser surgery for severe second trimester twin-to-twin transfusion syndrome (TTTS) treated at our centre. Method: A total of 100 consecutive pregnancies with severe second trimester TTTS treated at our centre with selective fetoscopic laser coagulation of vascular anastomoses on the placental surface between August 2000 and November 2004 were included in the study. Perinatal survival was analysed in relation to Quintero stage. Results: Median gestational age was 20 weeks at fetoscopy (range: 16–26) and 33 weeks at delivery (range: 18–40). Perinatal survival rate was 70% (139/200). The treatment resulted in at least one survivor at the age of 4 weeks in 81% of pregnancies. Perinatal survival was significantly higher when treatment was performed in the early Quintero stages (95% in stage 1, 76% in stage 2, 70% in stage 3, 50% in stage 4) (p = 0.02). Conclusion: Results of fetoscopic laser surgery for TTTS in our centre are similar to those in specialised centres in other countries. Diagnosis and treatment in the early Quintero stages resulted in significantly higher perinatal survival.

Published
2006

23. Subject Index Vol. 22, 2007

Author

Yiannis Tselentis, O. Koukoura, S Vashisht, E. Avgoustinakis, N. Sagawa, Aris Antsaklis, Eleftheria Hatzidaki, Dimitra Lambraki, Mark P. Johnson, Johanna M. Middeldorp, William H. Peranteau, I. Koutras, Frank P.H.A. Vandenbussche, N. Murabayashi, Stephanie Schleider, Johannes M.P.J. Breur, N. Scott Adzick, Stavros Sifakis, Nikolaos Papantoniou, Erik J. Meijboom, Heidi Kühling-von Kaisenberg, N. Mantas, Kypros H. Nicolaides, Constantin von Kaisenberg, Axel Heep, Yao-Lung Chang, Dick Oepkes, Michael Bebbington, Radoslav Herman, Frans J.C.M. Klumper, Hilde Van Decruyes, Dubravko Habek, Cem Dane, G. Clerici, Tarun Jain, Figen Aksoy, Enrico Lopriore, Lars Venhoff, Jan Ringers, Raju Sharma, Mark I. Evans, Alan W. Flake, Winfried A. Willinek, Philip Stoutenbeek, Banu Dane, Peter Bartmann, Yung-Kuei Soong, E. Koumantakis, Ahmet Cetin, R. Luzietti, Paul P. van den Berg, Ioannis Katsoulis, Christina Giannakopoulou, Rob H. J. M. Gooskens, Jenn-Jein Hsu, Livia Kapusta, Andreas Müller, Eftichia Korakaki, H. Kusaka, Axel R. Franz, Murat Yayla, Shuenn-Dyh Chang, Ulrich Gembruch, S. Sifakis, G. C. Di Renzo, Rohini Gupta, Holly L. Hedrick, Aida Salihagić, Emmanouil Galanakis, Gerard H. A. Visser, Thomas Kohl, Frank W. Jansen, Maria Antoniou, Domagoj Jugović, Antonia Manoura, Marieke Sueters, R. Douglas Wilson, T. Sugiyama, Ivo Meinhold-Heerlein, An-Shine Chao, Sandra Grebe, Ioannis Papageorgiou, and Aziz M. Merchant

Subjects
Embryology, Index (economics), business.industry, Pediatrics, Perinatology and Child Health, Statistics, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, Subject (documents), General Medicine, business
Published
2007

24. Contents Vol. 18, 2003

Author

Roderick F. Hume, Marie Helene Poissonnier, Marco De Santis, Mark P. Johnson, Mark I. Evans, Artúr Beke, Katinka A.K. Teunissen, R. Oberhoffer, Jacques Lepercq, Asher Bashiri, Moshe Mazor, Howard K. Kaufman, H.E. Mighty, Yasushi Kaji, Zoltán Papp, Frans J.C.M. Klumper, Victoria Yorke, C.R. Harman, Timothy M. Crombleholme, M. Tollens, Delia M. Paternoster, Tadashi Matsumoto, A. Cristina Rossi, Alan W. Flake, Britta Christensen, Luigi Selvaggi, Antonella Vimercati, Oluyinka O. Olutoye, Evangelos Paraskevaidis, Nancy Carlson, N. Scott Adzick, Esther Sikkel, Takeshi Maruo, D. Grab, Jasna Čerkez Habek, Kazuro Sugimura, John Philip, Alessandro Caruso, Reli Hershkovitz, Keisuke Ishii, A.A. Baschat, Yoshihito Sasaki, Maria Scavo, Ehud Zmora, Yves Brossard, M.V. Muench, Francesca Manganelli, Steen Kølvraa, Dawn Elliott, E. Tóth-Pál, P. Barbet, Dick Oepkes, Minas Paschopoulos, Costantino Romagnoli, Yasunori Yoshimura, Robertjan H. Meerman, Wolfgang Moroder, Pantaleo Greco, Zoltán Bán, Dubravko Habek, Lene Lykke-Hansen, Kazushige Ikeda, Eyal Sheiner, F. Bargy, Olivier Picone, Kyousuke Takeuchi, D. Lang, Francesco Giorgino, Beverly G. Coleman, Bálint Nagy, Evangelos G.E. Papanikolaou, Mirjana Jagušt, Umberto Nicolini, Csaba Papp, Fiammetta Piersigilli, George Makrydimas, Lucia Masini, Kazuya Kawamata, Humphrey H.H. Kanhai, S. Beaudoin, Yoshihiko Yamanaka, Byron C. Calhoun, Giuseppe Noia, Mamoru Tanaka, Kei Miyakoshi, Saskia le Cessie, Ilana Shoham-Vardi, Frank P.H.A. Vandenbussche, Marco Scioscia, J. Hess, Shozo Matsuoka, Hitoshi Ishimoto, Susumu Miyashita, Kenji Kasai, Yoshihide Chiba, and Dimitrios Lolis

Subjects
Embryology, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, business
Published
2003

25. Subject Index Vol. 18, 2003

Author

Minas Paschopoulos, Keisuke Ishii, Antonella Vimercati, Yasunori Yoshimura, Evangelos G.E. Papanikolaou, A.A. Baschat, C.R. Harman, Mirjana Jagušt, Reli Hershkovitz, Timothy M. Crombleholme, N. Scott Adzick, S. Beaudoin, Yoshihiko Yamanaka, Marco Scioscia, Alan W. Flake, Yoshihito Sasaki, Frank P.H.A. Vandenbussche, Nancy Carlson, M. Tollens, Wolfgang Moroder, Dimitrios Lolis, Yasushi Kaji, Steen Kølvraa, Francesca Manganelli, Frans J.C.M. Klumper, J. Hess, Esther Sikkel, Victoria Yorke, Shozo Matsuoka, Dick Oepkes, Bálint Nagy, John Philip, Mark I. Evans, Olivier Picone, D. Lang, Humphrey H.H. Kanhai, E. Tóth-Pál, Jacques Lepercq, Britta Christensen, Robertjan H. Meerman, Maria Scavo, Marco De Santis, Dubravko Habek, Yves Brossard, Pantaleo Greco, Beverly G. Coleman, Hitoshi Ishimoto, Roderick F. Hume, Susumu Miyashita, Jasna Čerkez Habek, Zoltán Papp, Saskia le Cessie, Kenji Kasai, M.V. Muench, Kyousuke Takeuchi, Yoshihide Chiba, P. Barbet, Ilana Shoham-Vardi, Ehud Zmora, Lene Lykke-Hansen, Csaba Papp, Fiammetta Piersigilli, George Makrydimas, Artúr Beke, Umberto Nicolini, Eyal Sheiner, Marie Helene Poissonnier, Francesco Giorgino, Kazuro Sugimura, Mark P. Johnson, Byron C. Calhoun, Mamoru Tanaka, Lucia Masini, Dawn Elliott, Giuseppe Noia, Luigi Selvaggi, Takeshi Maruo, Kei Miyakoshi, Delia M. Paternoster, Kazuya Kawamata, Tadashi Matsumoto, Asher Bashiri, Moshe Mazor, F. Bargy, Howard K. Kaufman, H.E. Mighty, Costantino Romagnoli, D. Grab, Kazushige Ikeda, A. Cristina Rossi, Oluyinka O. Olutoye, Zoltán Bán, Katinka A.K. Teunissen, Evangelos Paraskevaidis, R. Oberhoffer, and Alessandro Caruso

Subjects
Gerontology, Embryology, Index (economics), business.industry, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Medicine, Radiology, Nuclear Medicine and imaging, Subject (documents), General Medicine, business
Published
2003

26. Reply

Author

D. Papathanasiou, Ruben S G M Witlox, K.W.M. Bloemenkamp, Frans J. Walther, Enrico Lopriore, and Dick Oepkes

Subjects
Gynecology, Embryology, Fetus, medicine.medical_specialty, business.industry, Pediatrics, Perinatology and Child Health, medicine, Vasa Previa, Obstetrics and Gynecology, Radiology, Nuclear Medicine and imaging, General Medicine, Monochorionic twins, business
Published
2011

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