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Start Over Topic immune system Publication Year Range Last 3 years Journal fish & shellfish immunology
2 results

1. The mucosal immunity in crustaceans: Inferences from other species.

Author

Hao, Ruixue, Zhao, Mingming, Tayyab, Muhammad, Lin, Zhongyang, and Zhang, Yueling

Subjects
*IMMUNOLOGIC memory, *NATURAL immunity, *CELLULAR immunity, *LYMPHATICS, *IMMUNE system
Abstract

Crustaceans such as shrimps and crabs, hold significant ecological significance and substantial economic value within marine ecosystems. However, their susceptibility to disease outbreaks and pathogenic infections has posed major challenges to production in recent decades. As invertebrate, crustaceans primarily rely on their innate immune system for defense, lacking the adaptive immune system found in vertebrates. Mucosal immunity, acting as the frontline defense against a myriad of pathogenic microorganisms, is a crucial aspect of their immune repertoire. This review synthesizes insights from comparative immunology, highlighting parallels between mucosal immunity in vertebrates and innate immune mechanisms in invertebrates. Despite lacking classical adaptive immunity, invertebrates, including crustaceans, exhibit immune memory and rely on inherent "innate immunity factors" to combat invading pathogens. Drawing on parallels from mammalian and piscine systems, this paper meticulously explores the complex role of mucosal immunity in regulating immune responses in crustaceans. Through the extrapolation from well-studied models like mammals and fish, this review infers the potential mechanisms of mucosal immunity in crustaceans and provides insights for research on mucosal immunity in crustaceans. • Mucosal immunity parallels cellular and humoral immunity and interacts closely with the lymphatic system. • Vertebrate mucosal immunity shows significant convergence with invertebrate innate immunity. • Mucosal immunity probably exists in crustaceans. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Transcriptome analysis of Neocaridina denticulate sinensis challenged by Vibrio parahemolyticus

Author

Kefan Xing, Jiquan Zhang, Congcong Yan, Yongzhao Zhou, Xuemei Xu, Yuying Sun, and Yujie Liu

Subjects
Genetics, biology, Gene Expression Profiling, Vibrio parahaemolyticus, Hepatopancreas, General Medicine, Aquatic Science, biology.organism_classification, Immunity, Innate, Shrimp, Transcriptome, Neocaridina, Immune system, Decapoda, Vibrio Infections, Animals, Environmental Chemistry, Gene, Pathogen
Abstract

As a common aquatic pathogen, Vibrio parahaemolyticus can cause a variety of diseases of shrimp, especially acute hepatopancreatic necrosis disease (AHPND), which leads to great losses to the aquaculture industry around the world. However, the molecular mechanism of V. parahaemolyticus infection is still unclear. Neocaridina denticulate sinensis is a kind of small ornamental shrimp that is popular in aquarium trade, and due to its tenacious vitality, rapid growth, high reproductive capacity, it is very suitable to be developed as an animal model for basic research on decapod crustaceans. Thus, in this paper, transcriptomes of N. denticulate sinensis hepatopancreas with or without V. parahaemolyticus injection were explored. The results showed that a total of 23,624 genes with the N50 of 2705 bp were obtained. Comparative transcriptomic analysis revealed 21,464 differentially expressed genes between the V. parahaemolyticus infected and non-infected group, of which, 11,127 genes were up-regulated and 10,337 genes were down-regulated. Functional enrichment analysis suggested that many DEGs enriched in immune related pathways, including MAPK signaling pathway, Phosphatidylinositol signaling system, Chemokine signaling pathway, Phagosome and Jak-STAT signaling pathway and so on. Eight genes were selected randomly for qRT-PCR to verify the transcriptome sequencing results and the results showed the expression of these genes were consistent with the transcriptome results. Our work provides a unique and important dataset that contributes to the understanding of the molecular mechanisms of the immune response to V. parahaemolyticus infection and may further provide the basis for the prevention and resolution of bacterial diseases.

Published
2022