1. Immunotoxicity and hepatic function evaluation in Nile tilapia (Oreochromis niloticus) exposed to diazinon
- Author
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Jorge Peregrina-Sandoval, Galina Zaitseva, Akiro Takemura, Anne Santerre, Marcela Hernández-Coronado, Fabiola Gonzalez-Jaime, Manuel Iván Girón-Pérez, and Josefina Casas-Solís
- Subjects
Veterinary medicine ,Diazinon ,Spleen ,Aquatic Science ,Biology ,Median lethal dose ,Lethal Dose 50 ,chemistry.chemical_compound ,Nile tilapia ,Phagocytosis ,medicine ,Splenocyte ,Environmental Chemistry ,Animals ,Cell Proliferation ,General Medicine ,Cichlids ,Organ Size ,Pesticide ,biology.organism_classification ,Acute toxicity ,Enzymes ,Oreochromis ,medicine.anatomical_structure ,chemistry ,Immunoglobulin M ,Liver ,Immune System ,Immunology ,Water Pollutants, Chemical - Abstract
The LC(50) of the organophosphorus pesticides (OPs) diazinon to Nile tilapia (Oreochromis niloticus) was determined, thereafter, hepatic activity, phagocytic index, percentages of active cells, relative spleen weight, total IgM concentration and lymphoproliferation rates were compared between diazinon exposed groups (LC(50) and (1/2)LC(50)) and non-exposed control group. Experimental data show that diazinon is highly toxic for juvenile Nile tilapia (LC(50)=7.830 ppm) and presents immunotoxic properties which affect both the innate and cellular adaptive immune responses of this fish, as revealed by the fact that splenocyte proliferation and phagocytic indices were significantly decreased after acute exposure to the pesticide. However, the hepatic biochemical parameters and the total circulating IgM concentrations were not affected in this experimental model.
- Published
- 2006