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Your search keyword '"Ren, Yi"' showing total 3 results
3 results on '"Ren, Yi"'

1. Antioxidant flavonoids from the seed of Oroxylum indicum

Author

Yan, Ren-yi, Cao, Yang-yang, Chen, Cheng-yu, Dai, Hui-qing, Yu, Sheng-xian, Wei, Jie-lin, Li, Hua, and Yang, Bin

Subjects
*MEDICINAL plants, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANTIOXIDANTS, *BIOLOGICAL assay, *BIOPHYSICS, *PHYSICAL & theoretical chemistry, *CHROMATOGRAPHIC analysis, *DOSE-effect relationship in pharmacology, *FLAVONOIDS, *GLYCOSIDES, *HIGH performance liquid chromatography, *RESEARCH methodology, *RESEARCH funding, *SEEDS, *PHYTOCHEMICALS, *PLANT extracts
Abstract

Abstract: Three new flavonoid glycosides (1–3) and nineteen known compounds (4–22) were isolated from the aqueous ethanolic extract of the seed of Oroxylum indicum. The structures of 1–3 were elucidated on the basis of spectroscopic analysis. Antioxidant activities of all the isolated compounds were evaluated using a DPPH and an ORAC assay. Compounds 3, 5–7, 9 and 12 exhibited potent antioxidant activity in the DPPH assay, while compounds 3–15 showed potent antioxidant capacity in the ORAC assay, and seven antioxidant flavonoids (4–6, 8, 9, 11, 12) were detected as the main ingredients in the methanolic extract of seed of O. indicum using an HPLC analysis. [Copyright &y& Elsevier]

Published
2011
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2. Three new water-soluble alkaloids from the leaves of Suregada glomerulata (Blume) Baill

Author

Yan, Ren-Yi, Wang, Hong-Qing, Liu, Chao, Chen, Ruo-Yun, and Yu, De-Quan

Subjects
*HIV prevention, *MEDICINAL plants, *ALKALOIDS, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *BIOLOGICAL assay, *BIOLOGICAL models, *BIOPHYSICS, *PHYSICAL & theoretical chemistry, *LEAVES, *RESEARCH methodology, *RATS, *RESEARCH funding, *PLANT extracts
Abstract

Abstract: Three new water-soluble alkaloids (1–3) together with twelve known compounds (4–15) have been isolated from the water extract of leaves of Suregada glomerulata. Their structures were determined by spectroscopic analysis and chemical method. Compounds 1–3 were evaluated for their in vitro inhibitory activity against α-glucosidase and HIV-1 replication. However, no significant activities were found. [Copyright &y& Elsevier]

Published
2011
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3. Melosuavine I, an apoptosis-inducing bisindole alkaloid from Melodinus suaveolens.

Author

Fang ZY, Ren YD, Du SY, Zhang M, Wang YS, Fang L, and Zhang H

Subjects
Antineoplastic Agents, Phytogenic isolation & purification, Caspase 3 metabolism, Cell Line, Tumor, Cell Proliferation drug effects, China, Drug Screening Assays, Antitumor, Humans, Indole Alkaloids isolation & purification, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Leaves chemistry, Proto-Oncogene Proteins c-bcl-2 metabolism, Tumor Suppressor Protein p53 metabolism, Antineoplastic Agents, Phytogenic pharmacology, Apocynaceae chemistry, Apoptosis drug effects, Indole Alkaloids pharmacology
Abstract

A new bisindole alkaloid, melosuavine I (1) possessing an aspidosperma-aspidosperma dimeric skeleton, was isolated from the leaves of Melodinus suaveolens. The structure with absolute configuration of 1 was elucidated by a combination of MS, NMR and computational methods. MTT assays indicated that 1 exhibited significant cytotoxicity on human breast cancer BT549 cells with an IC 50 value of 0.89 μM. Further study showed that 1 inhibited BT549 cell proliferation by inducing apoptosis through activation of caspase 3 and p53, and down-regulation of Bcl-2., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2019
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