1. Two new lignans from Saururus chinensis and their DGAT inhibitory activity.
- Author
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Li N, Tuo ZD, Qi SZ, Xing SS, Lee HS, Chen JG, and Cui L
- Subjects
- Enzyme Inhibitors isolation & purification, HEK293 Cells, Humans, Inhibitory Concentration 50, Lignans isolation & purification, Molecular Structure, Plant Roots chemistry, Diacylglycerol O-Acyltransferase antagonists & inhibitors, Enzyme Inhibitors chemistry, Lignans chemistry, Saururaceae chemistry
- Abstract
Two new lignans were isolated from Saururus chinensis, along with eight known compounds. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 2, 3, 5 and 7 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 44.3±1.5 to 87.5±1.3μM., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2015
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