1. Two new lignans from Saururus chinensis and their DGAT inhibitory activity.
- Author
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Li, Na, Tuo, Zhen-Dong, Qi, Shi-Zhou, Xing, Shan-Shan, Lee, Hyun-Sun, Chen, Jian-Guang, and Cui, Long
- Subjects
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ALTERNATIVE medicine , *PHYSICAL & theoretical chemistry , *DOSE-effect relationship in pharmacology , *ENZYME inhibitors , *LIGNANS , *MEDICINAL plants , *SPECTRUM analysis , *PHYTOCHEMICALS , *PLANT extracts , *DESCRIPTIVE statistics , *IN vitro studies , *PHARMACODYNAMICS - Abstract
Two new lignans were isolated from Saururus chinensis , along with eight known compounds. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 2 , 3 , 5 and 7 were found to exhibit selective inhibitory activity on DGAT1 with IC 50 values ranging from 44.3 ± 1.5 to 87.5 ± 1.3 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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