Search

Five undescribed eremophilane-type sesquiterpenes, remophilanetriols E -I (1 – 5), along with seven known compounds (6 – 12) were isolated from the fresh roots of Rehmannia glutinosa. Their structures were characterized by extensive spectroscopic data analysis and their absolute configurations were determined by comparing their calculated electronic circular dichroism (ECD) spectra and experimental ECD spectra. The anti-pulmonary fibrosis activities of all compounds were evaluated in vitro by MTT methods, and compounds 2 , 8 , 10 , and 12 exhibited excellent anti-pulmonary fibrosis activities. In addition, compound 2 can reduce the levels of ROS and apoptosis in TGF-β1-induced BEAS-2B cells. [Display omitted] [ABSTRACT FROM AUTHOR]

Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity. The bioactivity-guided isolation led to the separation of two new compounds, (±)-tradescantin ( 13 ) and tradescantoside ( 16 ), along with fourteen known compounds ( 1 – 12 , 14 , and 15 ) from the aerial parts of Tradescantia spathacea Sw. (Commelinaceae). Their chemical structures were elucidated by spectroscopic methods as well as by comparing with those reported in the literature. The isolated compounds ( 1 – 16 ) were then examined for their inhibitory activity toward PTP1B. The results indicated that compounds 2 , 6 , 8 , and 12 possessed potent inhibition with IC 50 values of 7.82 ± 0.79, 6.80 ± 0.89, 4.55 ± 0.92, and 6.38 ± 0.14 μM, respectively. Kinetic study of compounds 2 , 6 , 8 , 12 , 13 , and 16 was conducted and the structure–activity relationships of the isolated compounds ( 1 – 16 ) were also discussed herein. To the best of our knowledge, all the isolates were separated for the first time from this plant. [ABSTRACT FROM AUTHOR]