1. Terpenoids from the stems of Celastrus hindsii and their anti-RSV activities.
- Author
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Luo, Ding, Xiong, Si, Li, Qing-Guo, Jiang, Lin, Niu, Qian-Wen, He, Li-Jun, Li, Yao-Lan, Zhang, Yu-Bo, and Wang, Guo-Cai
- Subjects
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BIOLOGICAL assay , *CELL culture , *CHROMATOGRAPHIC analysis , *HIGH performance liquid chromatography , *MASS spectrometry , *CHINESE medicine , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *RESEARCH funding , *SPECTROPHOTOMETRY , *PLANT stems , *TERPENES , *THIN layer chromatography , *PLANT extracts , *RESPIRATORY syncytial virus infections , *IN vitro studies - Abstract
Abstract Two new oleanane-type triterpenoids (1 – 2), a new ursane-type triterpenoid (3), and a new podocarpane-type diterpenoid (4), together with 20 known compounds (5 – 24) were isolated from the stems of Celastrus hindsii Benth. Their structures were identified on the basis of the spectral data (HRESIMS, IR, UV, 1D, and 2D NMR) and the absolute configurations were determined by comparison of experimental and calculated ECD data. The structures of 1 and 4 were further confirmed by single crystal X-ray diffraction analysis. In addition, all compounds were evaluated for their in vitro antiviral activities against respiratory syncytium virus (RSV) using cytopathic effect (CPE) reduction assay. Compounds 7 , 10 , 11 , 19 and 24 exhibited obvious anti-RSV activity with IC 50 values from 1.55 to 6.25 μM. Graphical abstract Unlabelled Image [ABSTRACT FROM AUTHOR]
- Published
- 2018
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