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Your search keyword '"Aconitum coreanum"' showing total 2 results
Start Over Descriptor "Aconitum coreanum" Journal fitoterapia
2 results on '"Aconitum coreanum"'

1. New diterpenoid alkaloids from Aconitum coreanum and their anti-arrhythmic effects on cardiac sodium current.

Author

Xing, Bei-Ni, Jin, Si-Si, Wang, Hao, Tang, Qing-Fa, Liu, Jing-Han, Li, Rui-Yang, Liang, Jing-Yu, Tang, Yi-Qun, and Yang, Chun-Hua

Subjects
*ALKALOIDS, *ALTERNATIVE medicine, *PHYSICAL & theoretical chemistry, *COMPARATIVE studies, *DOSE-effect relationship in pharmacology, *MEDICINAL plants, *MYOCARDIAL depressants, *NUCLEAR magnetic resonance spectroscopy, *PLANT roots, *PLANT extracts, *DESCRIPTIVE statistics, *PHARMACODYNAMICS
Abstract

Abstract: Two new diterpenoid alkaloids, Guan-Fu base J (GFJ, 1) and Guan-Fu base N (GFN, 2) along with nineteen known alkaloids (3–21) were isolated from the roots of Aconitum coreanum (Lèvl.) Rapaics, which is the raw material of a new approval anti-arrhythmia drug “Acehytisine Hydrochloride”. The structures of isolated compounds were established by means of 1D, 2D NMR spectroscopic and chemical methods. All isolates obtained in the present study were evaluated for their inhibitory effects on blocking the ventricular specific sodium current using a whole-cell patch voltage-clamp technique. Among these 21 compounds, Guan-Fu base S (GFS, 3) showed the strongest inhibitory effect with an IC50 value of 3.48μM, and only hetisine-type C20 diterpenoid alkaloids showed promising IC50 values for further development. [Copyright &y& Elsevier]

Published
2014
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2. New diterpenoid alkaloids from Aconitum coreanum and their anti-arrhythmic effects on cardiac sodium current

Author

Yi-Qun Tang, Qingfa Tang, Jing-Han Liu, Hao Wang, Xing Beini, Chunhua Yang, Rui-Yang Li, Si-Si Jin, and Jing-Yu Liang

Subjects
Male, Magnetic Resonance Spectroscopy, Patch-Clamp Techniques, Stereochemistry, Hydrochloride, Guinea Pigs, Plant Roots, Membrane Potentials, Sodium current, Inhibitory Concentration 50, Acehytisine, chemistry.chemical_compound, Alkaloids, Drug Discovery, Animals, Anti arrhythmic, Myocytes, Cardiac, IC50, Pharmacology, Aconitum, Dose-Response Relationship, Drug, Molecular Structure, biology, Traditional medicine, Plant Extracts, Sodium, General Medicine, biology.organism_classification, Terpenoid, Aconitum coreanum, chemistry, Diterpenes, Anti-Arrhythmia Agents, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

Two new diterpenoid alkaloids, Guan-Fu base J (GFJ, 1) and Guan-Fu base N (GFN, 2) along with nineteen known alkaloids (3-21) were isolated from the roots of Aconitum coreanum (Lèvl.) Rapaics, which is the raw material of a new approval anti-arrhythmia drug "Acehytisine Hydrochloride". The structures of isolated compounds were established by means of 1D, 2D NMR spectroscopic and chemical methods. All isolates obtained in the present study were evaluated for their inhibitory effects on blocking the ventricular specific sodium current using a whole-cell patch voltage-clamp technique. Among these 21 compounds, Guan-Fu base S (GFS, 3) showed the strongest inhibitory effect with an IC50 value of 3.48 μM, and only hetisine-type C20 diterpenoid alkaloids showed promising IC50 values for further development.

Published
2014

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