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Your search keyword '"Baccharis dracunculifolia"' showing total 5 results
Start Over Descriptor "Baccharis dracunculifolia" Journal fitoterapia
5 results on '"Baccharis dracunculifolia"'

1. In vivo anti-inflammatory activity of BACCHARIN from BRAZILIAN green PROPOLIS.

Author

Almeida-Junior, Silvio, de Oliveira, Kátia Roberta Prieto, Marques, Laís Prado, Martins, João Guilherme, Ubeda, Heloisa, Santos, Mario Ferreira Conceição, Rodrigues, Marcela Aldrovani, Andrade e Silva, Marcio Luís, Ambrósio, Sérgio Ricardo, Bastos, Jairo Kenupp, Ross, Samir A., and Furtado, Ricardo Andrade

Subjects
*INFLAMMATION prevention, *ANTI-inflammatory agents, *NF-kappa B, *HEEL (Anatomy), *TISSUES, *FOOT, *EDEMA, *IN vivo studies, *PROPOLIS, *PLANT extracts, *ANALGESICS, *GENE expression, *MEDICINAL plants, *ANIMAL experimentation, *BIOLOGICAL assay, *HISTOLOGY, *PHARMACODYNAMICS
Abstract

Baccharin is one of the major compounds found in Brazilian green propolis and its botanical source, Baccharis dracunculifolia. Considering the biological effects of propolis and B. dracunculifolia, this study aims to evaluate the analgesic and anti-inflammatory potential of baccharin. The neurodepressor potential was performed by the open field test, analgesia by mechanical stimulation with Dynamic Plantar Aesthesiometer, and by thermal stimulation with Hargreaves apparatus. In addition, the anti-inflammatory potential was achieved by the paw edema assay, histopathological evaluation, and NF-kB expression. Doses of 2.5, 5, and 10 mg/kg of baccharin were evaluated. After euthanasia, plantar tissue was collected and prepared for histology. As a result, analgesic activity was observed at a dose of 10 mg/kg of baccharin in thermal stimulation under an inflammatory process and anti-inflammatory potential at a dose of 5 mg/kg of baccharin from the second hour in the paw edema test. A decrease in cellular infiltrate and down-modulation of NF-kB, besides the reduction of edema in the histopathology was observed. There was no evidence of kidney and liver toxicity and neurodepressive potential at the doses tested. Thus, baccharin has a promising anti-inflammatory effect possibly associated with antiedematogenic activity by inhibiting mediators such as prostaglandins, inhibiting the migration of polymorphonuclear cells, and modulating NF-kB expression. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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2. Artepillin C: A comprehensive review of its chemistry, bioavailability, and pharmacological properties

Author

Rashiduzzaman Emran, Patricia Rozario, Diana N. Obanda, Shahinozzaman, and Bristy Basak

Subjects
Biological Availability, Pharmacology, 01 natural sciences, Neuroprotection, Baccharis dracunculifolia, In vivo, Drug Discovery, Animals, Humans, Arc (protein), biology, Phenylpropionates, 010405 organic chemistry, Baccharis, Plant Extracts, SARS-CoV-2, General Medicine, Propolis, biology.organism_classification, Antimicrobial, 0104 chemical sciences, Bioavailability, COVID-19 Drug Treatment, 010404 medicinal & biomolecular chemistry
Abstract

Artepillin C (ARC), a prenylated derivative of p-coumaric acid, is one of the major phenolic compounds found in Brazilian green propolis (BGP) and its botanical source Baccharis dracunculifolia. Numerous studies on ARC show that its beneficial health effects correlate with the health effects of both BGP and B. dracunculifolia. Its wide range of pharmacological benefits include antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, neuroprotective, gastroprotective, immunomodulatory, and anti-cancer effects. Most studies have focused on anti-oxidation, inflammation, diabetic, and cancers using both in vitro and in vivo approaches. Mechanisms underlying anti-cancer properties of ARC are apoptosis induction, cell cycle arrest, and the inhibition of p21-activated kinase 1 (PAK1), a protein characterized in many human diseases/disorders including COVID-19 infection. Therefore, further pre-clinical and clinical studies with ARC are necessary to explore its potential as intervention for a wide variety of diseases including the recent pandemic coronaviral infection. This review summarizes the comprehensive data on the pharmacological effects of ARC and could be a guideline for its future study and therapeutic usage.

Published
2020

3. In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae)

Author

Filho, A.A. da Silva, Resende, D.O., Fukui, M.J., Santos, F.F., Pauletti, P.M., Cunha, W.R., Silva, M.L.A., Gregório, L.E., Bastos, J.K., and Nanayakkara, N.P.D.

Subjects
*PHENOLS, *TERPENES, *BACCHARIS, *ASTERACEAE, *LEISHMANIA, *PLASMODIUM falciparum
Abstract

Abstract: Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC50 value of 45µg/mL, while GPE presented an IC50 value of 49µg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC50 values of 3.7µg/mL and 7.0µg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC50 values (about 20µg/mL), while Hautriwaic acid lactone led to an IC50 value of 0.8µg/mL (D6 clone). [Copyright &y& Elsevier]

Published
2009
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4. Artepillin C: A comprehensive review of its chemistry, bioavailability, and pharmacological properties.

Author

Shahinozzaman, Md, Basak, Bristy, Emran, Rashiduzzaman, Rozario, Patricia, and Obanda, Diana N.

Subjects
*ANTI-infective agents, *ANTI-inflammatory agents, *ANTINEOPLASTIC agents, *ANTIOXIDANTS, *BIOAVAILABILITY, *BREAST tumors, *COLON tumors, *HYPOGLYCEMIC agents, *IMMUNOLOGICAL adjuvants, *KIDNEY tumors, *LEUKEMIA, *LUNG tumors, *NEUROFIBROMATOSIS, *PHENOLS, *PROPOLIS, *PROSTATE tumors, *SERIAL publications, *NEUROPROTECTIVE agents, *CARBOCYCLIC acids, CERVIX uteri tumors
Abstract

Artepillin C (ARC), a prenylated derivative of p -coumaric acid, is one of the major phenolic compounds found in Brazilian green propolis (BGP) and its botanical source Baccharis dracunculifolia. Numerous studies on ARC show that its beneficial health effects correlate with the health effects of both BGP and B. dracunculifolia. Its wide range of pharmacological benefits include antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, neuroprotective, gastroprotective, immunomodulatory, and anti-cancer effects. Most studies have focused on anti-oxidation, inflammation, diabetic, and cancers using both in vitro and in vivo approaches. Mechanisms underlying anti-cancer properties of ARC are apoptosis induction, cell cycle arrest, and the inhibition of p21-activated kinase 1 (PAK1), a protein characterized in many human diseases/disorders including COVID-19 infection. Therefore, further pre-clinical and clinical studies with ARC are necessary to explore its potential as intervention for a wide variety of diseases including the recent pandemic coronaviral infection. This review summarizes the comprehensive data on the pharmacological effects of ARC and could be a guideline for its future study and therapeutic usage. Unlabelled Image [ABSTRACT FROM AUTHOR]

Published
2020
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5. In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae)

Author

M.J. Fukui, L.E. Gregório, Npd Nanayakkara, Wilson Roberto Cunha, AA Da Silva Filho, D.O. Resende, FF Santos, Jairo Kenupp Bastos, Patrícia Mendonça Pauletti, and Márcio Luis Andrade e Silva

Subjects
Stereochemistry, Plasmodium falciparum, Microbial Sensitivity Tests, Propolis, chemistry.chemical_compound, Ermanin, Antimalarials, Baccharis dracunculifolia, Ursolic acid, Parasitic Sensitivity Tests, Phenols, parasitic diseases, Drug Discovery, Chlorocebus aethiops, Animals, Medicinal plants, Vero Cells, Pharmacology, chemistry.chemical_classification, Acacetin, biology, Traditional medicine, Plant Extracts, General Medicine, Asteraceae, biology.organism_classification, Trypanocidal Agents, Triterpenes, Plant Leaves, Baccharis, chemistry, Lactone, Leishmania donovani
Abstract

Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani, with an IC(50) value of 45 microg/mL, while GPE presented an IC(50) value of 49 microg/mL. Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 microg/mL and 7.0 microg/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 microg/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 microg/mL (D6 clone).

Published
2009

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