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2 results on '"He TT"'

1. Cytotoxic aspidosperma-type alkaloids from Melodinus suaveolens.

Author

Fang ZY, He TT, Du SY, Zhang M, Zhang YQ, and Fang L

Subjects
Alkaloids isolation & purification, Antineoplastic Agents, Phytogenic isolation & purification, Cell Line, Tumor, China, Humans, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Alkaloids pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Apocynaceae chemistry, Plant Leaves chemistry
Abstract

Four new aspidosperma-type alkaloids, melosuavines J-M (1-4) were isolated from the leaves of Melodinus suaveolens. Their structures with absolute configurations were elucidated by extensive HRESIMS and NMR spectroscopic analysis, as well as ECD calculations and Mosher's method. Their cytotoxic activities against four human cancer cell lines were also evaluated., Competing Interests: Declaration of Competing Interest Authors declare that there is no conflict of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Published
2020
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2. Two new polyketides from the roots of Stemona tuberosa.

Author

Fang L, Song XQ, He TT, Zhu KK, Yu JH, Song JT, Zhou J, and Zhang H

Subjects
Animals, Anti-Inflammatory Agents isolation & purification, Anti-Inflammatory Agents pharmacology, Cells, Cultured, China, Glucuronidase metabolism, Molecular Structure, Neutrophils drug effects, Plant Roots chemistry, Polyketides isolation & purification, Polyketides pharmacology, Rats, Anti-Inflammatory Agents chemistry, Polyketides chemistry, Stemonaceae chemistry
Abstract

Two polyketides, stemonones A (1) and B (2) with new skeletons, were isolated from the roots of Stemona tuberosa. Their absolute structures were fully characterized by comprehensive spectroscopic analyses and comparison of experimental electronic circular dichroism (ECD) spectra with calculated ones. The plausible biosynthetic pathways for 1 and 2 were also proposed. Anti-inflammatory assay confirmed that the two compounds showed moderate inhibitory effects on β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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