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14 results on '"Qin, Xu"'

7. New sphingolipids from the root of Isatis indigotica and their cytotoxic activity

Author

Dong-Dong Sun, Li-Wei He, Xiang Li, Han-Qing Zhang, Jian-Wei Chen, and Hui-Qin Xu

Subjects
Isatis indigotica, Pharmacognosy, Plant Roots, law.invention, Structure-Activity Relationship, law, Cell Line, Tumor, Drug Discovery, Humans, Cytotoxic T cell, Structure–activity relationship, Isatis, Pharmacology, Sphingolipids, Traditional medicine, biology, Plant Extracts, Chemistry, Mtt method, General Medicine, biology.organism_classification, Antineoplastic Agents, Phytogenic, Sphingolipid, Phytotherapy
Abstract

Two new sphingolipids were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as (2S,3R)-3-hydroxymethyl-N-(2'-hydroxynonacosanoyl)-trideca-9E-sphingenine(1) and 1-O-beta-D-glucopyranosyl-(2S,3R)-3-hydroxymethyl-N-(2'-hydroxynonacosanoyl)-trideca-9E-sphingenine(2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method.

Published
2007

9. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction

Author

Gao-Hong Lü, Taihui Fang, Bin Yu, Hui-Qin Xu, and Jin-Fu Lu

Subjects
Cardiac function curve, Male, medicine.medical_specialty, Myocardial Infarction, Hemodynamics, Microcirculation, Rats, Sprague-Dawley, Internal medicine, Drug Discovery, Medicine, Animals, Myocardial infarction, Buxus, Pharmacology, Heart Failure, Dose-Response Relationship, Drug, business.industry, Heart, General Medicine, medicine.disease, Rats, Dose–response relationship, Disease Models, Animal, Echocardiography, Heart failure, Circulatory system, Cardiology, Myocardial infarction complications, business, Drugs, Chinese Herbal
Abstract

The effect of Cyclovirobuxine D, an active ingredient from Buxus microphylla, was investigated in the potential prevention of cardiac dysfunction in rats with congestive heart failure. Heart failure was induced by left coronary artery occlusion and verified using echocardiography. Cyclovirobuxine D was administered for 30 days (0.5, 1.0 and 2.0 mg/kg, ig) and mortality, cardiac function, hemodynamics, microcirculation, histology and ultrastructure assessments were observed. Results from the present study suggest that Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction and supports the potential for Cyclovirobuxine D as a new therapy for heart failure.

Published
2011

14. C22-steroidal lactone glycosides from stems and leaves of Paris polyphylla var. yunnanensis

Author

Qin, Xu-Jie, Chen, Chang-Xiang, Ni, Wei, Yan, Huan, and Liu, Hai-Yang

Subjects
*ALTERNATIVE medicine, *ANTI-infective agents, *PHYSICAL & theoretical chemistry, *DOSE-effect relationship in pharmacology, *GLYCOSIDES, *LEAVES, *MEDICINAL plants, *MICROBIAL sensitivity tests, *SPECTRUM analysis, *PLANT stems, *PHYTOCHEMICALS, *PLANT extracts, *DESCRIPTIVE statistics, *IN vitro studies, *PHARMACODYNAMICS
Abstract

Abstract: Further phytochemical investigation on the stems and leaves of Paris polyphylla var. yunnanensis has led to the isolation of three C22-steroidal lactone glycosides. Two of these are new compounds, designated as chonglouoside SL-7 (1) and chonglouoside SL-8 (2). Their structures were elucidated on the basis of extensive spectroscopic analysis, as well as comparison with the reported spectroscopic data. This is the first report of C22-steroidal lactone glycosides isolated from the Paris genus. Compounds 1 and 3 showed moderate antimicrobic activity against Propionibacterium acnes with MIC values of 31.3 and 3.9μg/mL, respectively. [Copyright &y& Elsevier]

Published
2013
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