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Zizhines G–O (1 – 9), nine new meroterpenoids, and seven known analogs (10 – 16) were isolated from the dried fruiting bodies of Ganoderma sinensis. Their structures were identified by using spectroscopic data and CD curve comparison. The inhibitory activities of the selected new meroterpenoids toward AchE were assessed in vitro. Compounds 1 – 6 and 10 – 14 were found to exhibit AchE inhibitory activities at the concentration of 50 μM. Unlabelled Image [ABSTRACT FROM AUTHOR]

Two rare C 32 sesquiterpene lactone dimers, vlasouliolides J-K (1–2), together with three C 30 sesquiterpene dimers, vlasoulioliones A-C (3–5), were isolated from Vladimiria souliei . Their chemical structures were elucidated by NMR and MS spectroscopic data. Among them, compounds 1, 3 and 5 were unambiguously established by Cu-K α X-ray crystallographic analysis. Furthermore, compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC 50 value of 2.11 ± 0.35 μM. And the leakage of LDH from glutamate-induced PC-12 was significantly reduced by compound 1 at concentration of 10 μM. [ABSTRACT FROM AUTHOR]

Six new compounds, periplanetols A - F (1-4, 6 and 7), a compound isolated from natural origin for the first time (5), and nine known ones (8-16) were isolated from the 70% ethanol extract of the whole bodies of Periplaneta americana. Their structures including absolute configurations were unambiguously identified by comprehensive spectroscopic analyses and computational methods. Biological evaluation toward COX-2 inhibition revealed that compounds 1, 2, and 10 could inhibit COX-2 activity with the IC 50 values of 768.0 nM, 617.7 nM, and 599.5 nM respectively, indicating their potential in developping novel agents against inflammation related disorders., Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)