1. Three new alkaloids and three new phenolic glycosides from Liparis odorata
- Author
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Bin Li, Xuewen Lai, Genghua Zhu, Piao Jiang, Hongdong Liu, Xianghong Xu, Dong-Ming Zhang, Bo Liu, and Peng Xu
- Subjects
Magnetic Resonance Spectroscopy ,Stereochemistry ,Nitric Oxide ,Mass Spectrometry ,Cell Line ,Mice ,chemistry.chemical_compound ,Alkaloids ,Phenols ,Drug Discovery ,Animals ,Humans ,Bioassay ,Glycosides ,No production ,Orchidaceae ,Hypolipidemic Agents ,Pharmacology ,chemistry.chemical_classification ,Molecular Structure ,biology ,Alkaloid ,Glycoside ,Liparis odorata ,Hep G2 Cells ,General Medicine ,biology.organism_classification ,Liparis ,chemistry ,Microglia - Abstract
Three new alkaloids, liparis alkaloid A (1), B (2), C (3), and three new phenolic glycosides, liparis glycoside H (4), I (5), J (6), together with three known phenolic glycosides (7-9) were isolated from the whole plant of Liparis odorata. Their structures were characterized on the basis of extensive 1D-, 2D-NMR and HR-ESI-MS experiments. In addition, compounds 1-3 revealed hypolipidemic effects in the in vitro bioassays, and the ability to inhibit LPS-induced NO production of these isolated phenolic glycosides (4-9) was also evaluated.
- Published
- 2015
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