1. Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel.
- Author
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Gibby, W. A. T., Barabash, M. L., Guardiani, C., Luchinsky, D. G., Fedorenko, O. A., Roberts, S. K., and McClintock, P. V. E.
- Subjects
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STATISTICAL equilibrium , *MOLE fraction , *ION channels , *HUMAN behavior models , *THEORY - Abstract
The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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