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During the past decades, processing and engineering the drug particle using new proposed methods have gained an increasing attention. Among the different methods, using supercritical fluids technology is one of the most desired one. In this way, measuring and knowing the solubility of pharmaceuticals in supercritical fluids are one of the most critical parameters must be systematically categorized as a function of pressures and temperatures. Regarding this fact, solubility of fluvoxamine maleate in supercritical carbon dioxide in wide ranges of temperature (308–338 K) and pressure (200–400 bar) was measured using a static method coupled with gravimetric method which is in the range of 1.23 × 10 −5 to 4.45 × 10 −4 based on the mole fraction. Finally, the solubility data are modeled using four different semi-empirical density-based correlations namely Mendez Santiago-Teja (MST), Bartle et al., Chrastil and Kumar and Johnston (KJ) models. The obtained results reveal that amongst the utilized correlations, Chrastil model leads to the most accurate results compared with the other examined correlations with average absolute relative deviation percent (AARD%) of 10.8%. Besides, the solubility data are modeled using Peng–Robinson equation of state which no satisfactory results are obtained since the AARD% for all of the examined isotherms are in the range of 58.01–67.04%. [ABSTRACT FROM AUTHOR]

Vapor pressures and vaporization enthalpies for 5-nonanone, linalool and 6-methyl-5-hepten-2-one seem to be in disarray. Temperature dependences of vapor pressures for these pure compounds were measured by using the static and the transpiration techniques. Molar standard enthalpies of vaporization at the reference temperature were derived. Available literature data on vapor pressures and vaporization enthalpies were collected and analyzed. The consistent data set for each compound was evaluated. Reliable thermodynamic parameters of vaporization were derived and used to test some commonly used predicting procedures. [ABSTRACT FROM AUTHOR]

Abstract: The solubility of florfenicol in mixed 1,2-propanediol+water solvents was measured by a static analytical method at the temperature ranging from 293.15K to 316.25K. The experimental solubility data was correlated by the modified Apelblat equation, the General Single model and the Hybrid model. The results show that: the mole solubility of florfenicol in binary 1,2-propanediol+water mixtures increased with increasing temperature and the mole fraction of 1,2-propanediol in the binary solvent system; the values of the solubility calculated by the three models show good agreement with the experimental value; the OMPD from the modified Apelblat equation, the General Single model and the Hybrid model are 2.48, 2.07 and 5.12, respectively. However, compared to the modified Apelblat equation and the Hybrid model, the General Single model can give more accuracy and reliability of the solubility data. In addition, the discussion of the enthalpy and the entropy for florfenicol in different cosolvents indicated that the dissolution process of florfenicol was endothermic and entropy-driven. [Copyright &y& Elsevier]

Abstract: Vapor pressure of H2O+NaNO3 and H2O+NaNO2 solutions were measured with static method from 298.1 to 353.1K in a range of salt mass fractions between 0.05 and 0.50. As well, the vapor pressure was determined for quaternary mixtures LiNO3 +NaNO3 +KNO3 +H2O (salt mass ratio 53:5:42) and LiNO3 +KNO3 +NaNO2 +H2O (salt mass ratio 53:35:12) from 313.1 to 353.1K and total salt mass fraction of 0.30, 0.40 and 0.50. The experimental vapor pressure data of binary systems were correlated with the temperature and the liquid-phase composition using an analytical polynomial equation. The capability of the electrolyte non-random two liquid model (Electrolyte-NRTL) to predict the vapor–liquid equilibrium was evaluated by comparing predicted and experimental data of the mixtures studied in this work. [Copyright &y& Elsevier]

Abstract: Vapor pressure of methyl glycolate and the binary isothermal vapor–liquid equilibrium of ethylene glycol and methyl glycolate were measured by using static method. The experimental data was correlated with the Wilson and NRTL activity coefficient models. Good agreement between the experimental data and model is achieved. [Copyright &y& Elsevier]