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Start Over Author "Mahdi Asgari" Journal fluids and barriers of the cns
2 results on '"Mahdi Asgari"'

1. Barrier dysfunction or drainage reduction: differentiating causes of CSF protein increase

Author

Mahdi Asgari, Diane A. de Zélicourt, and Vartan Kurtcuoglu

Subjects
Spinal Canal, Dispersion Coefficient, Barrier Permeability, Spinal Subarachnoid Space, Albumin Quotient, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Cerebrospinal fluid (CSF) protein analysis is an important element in the diagnostic chain for various central nervous system (CNS) pathologies. Among multiple existing approaches to interpreting measured protein levels, the Reiber diagram is particularly robust with respect to physiologic inter-individual variability, as it uses multiple subject-specific anchoring values. Beyond reliable identification of abnormal protein levels, the Reiber diagram has the potential to elucidate their pathophysiologic origin. In particular, both reduction of CSF drainage from the cranio-spinal space as well as blood–CNS barrier dysfunction have been suggested ρas possible causes of increased concentration of blood-derived proteins. However, there is disagreement on which of the two is the true cause. Methods We designed two computational models to investigate the mechanisms governing protein distribution in the spinal CSF. With a one-dimensional model, we evaluated the distribution of albumin and immunoglobulin G (IgG), accounting for protein transport rates across blood–CNS barriers, CSF dynamics (including both dispersion induced by CSF pulsations and advection by mean CSF flow) and CSF drainage. Dispersion coefficients were determined a priori by computing the axisymmetric three-dimensional CSF dynamics and solute transport in a representative segment of the spinal canal. Results Our models reproduce the empirically determined hyperbolic relation between albumin and IgG quotients. They indicate that variation in CSF drainage would yield a linear rather than the expected hyperbolic profile. In contrast, modelled barrier dysfunction reproduces the experimentally observed relation. Conclusions High levels of albumin identified in the Reiber diagram are more likely to originate from a barrier dysfunction than from a reduction in CSF drainage. Our in silico experiments further support the hypothesis of decreasing spinal CSF drainage in rostro-caudal direction and emphasize the physiological importance of pulsation-driven dispersion for the transport of large molecules in the CSF.

Published
2017
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2. Abstracts from Hydrocephalus 2016

Author

Jamie Hoffberger, Karin Kockum, I. Jusué Torres, Fernando Hakim, M. Kang, David Cohen, Kemel A. Ghotme, Maria Kojoukhova, Armelle Lokossou, Juan Fernando Ramón, Jamie Robison, M. Vallejo, Otto Lilja-Lund, Anne M. Remes, Fredrik Lundin, Carlo Emanuel Petitto, Samir A Matloob, P. Sharkey, U. Kehler, Mark G. Luciano, A. Sattar, Shaokoon Cheng, M. Ishikawa, P. Saavedra, Tito Vivas-Buitrago, M. Flores, M. Schmid Daners, Hannah M. Tully, Juliana Benevenuto Tornai, Mahdi Asgari, Jussi Mattila, L. Mahieu, S. Foley, Lynne E. Bilston, Simon Garnotel, Jennifer Lu, Diane de Zélicourt, M. Hammad, Anders Eklund, Norman R. Relkin, Heimo Viinamäki, D. Moran, Stéphanie Salmon, David D. Limbrick, K. A. Carson, Ville E. Korhonen, J. A. Buttner-Ennever, S. D. Thompson, Nicolás Useche, D. Baghawatti, Ville Leinonen, Pierre Payoux, S. Mori, Eric A. Schmidt, S. Zuspan, Manuel Gehlen, Ossi Nerg, William G. Bradley, Daniel F. Hanley, D. M. Morales, K Onouchi, A. J. Luikku, W. Arouk, Rachel Dlugash, Seppo Helisalmi, M. A. Patel, L. D. Thorne, Anette Hall, C. García, Simon D Thompson, Paulo Cesar Modesto, M. W. Mancini, Abanti Sanyal, Gayane Yenokyan, L. Gray, Hugh F. Smisson, Mitja I. Kurki, Manoel Jacobsen Teixeira, Anne M Koivisto, S. Naqvi, P. Mayorga, Franz Marie Cruz, Deborah A Sival, C. Martinez, Joe Sam Robinson, Mikko Hiltunen, M. Mora, Debayan Dasgupta, Carmel Curtis, A. Buitrago, Gabriel André da Silva Mendes, M. Garzon, Laurent Balardy, K. Yamamoto, D. Kawaguchi, Vartan Kurtcuoglu, Anne Christine Januel, A. Hung, Eduardo Ortega, A. Häyrinen, Gregory James, Ari M. Blitz, Claudia Craven, T. Bach, P. Gantet, Jyrki Lötjönen, M. Timonen, Esteban M. Rodríguez, Mark G. Hamilton, L. D. Watkins, James P. McAllister, Ehud J. Schmidt, L. Murcia, V. Sousa, Andreas Eleftheriou, K. Carson, Fernando Campos Gomes Pinto, Heather Katzen, I. Jurjević, P. Haylock Vize, Masakazu Miyajima, Bryn A. Martin, Joshua Crawford, Zofia Czosnyka, D. Gomez, L. Al-Mutawa, Daniele Rigamonti, B. Bezerra, Benjamin D. Elder, M. A. Sevestre, P. Dutra, M. Jumaly, Gwenaël Pagé, K. Rigamonti, I. Moreno, Irina Alafuzoff, Monserrat Guerra, S. Yasar, H. A. Soto, Ahmed K Toma, D. Thompson, Irene Baudracco, Heinke Pülhorn, C. G. Valêncio, Eric W. Sankey, Walter A. Kukull, Harri Sintonen, Olivier Balédent, Alice Pong, H. Treviño, R. Jose, G. Calia, M. F. Oliveira, M. Dawood, Quoc Anh Thai, Karin Vío, A. J. Remolina, R. H. Maykot, Daniel A. Herzka, Arun Chandran, M. F. Cárdenas, Mikhail V. Pletnikov, Sanna-Kaisa Herukka, Lars Söderström, C. R. Goodwin, Jiadi Xu, Noam Alperin, Marcie R. Williams, K. Aquilina, K. Takagi, Maryoris Jara, K. Maitani, L. Almeida-Lopes, Christophe Cognard, K. Karagiozov, Alejandro P. Adam, Sonia Bermúdez, Katrine Riklund, Fabienne Ory-Magne, A. Guenego, T. Belcher, M. Zitoun, Diego Ernesto Lira González, Hugo Guerrero-Cazares, Eino Solje, Jussi Paananen, O. Omoush, Hisayuki Murai, Toshimasa Shin, M. A. Grijalba, Nelly Fabre, David Solomon, Sara Rodríguez, K. J. Whitehouse, K. I. Vanha, S. S. S. Silvestre, P. Tall, Juha E. Jääskeläinen, Per Hellström, H. Al-Ghamdi, Petra M. Klinge, Elna-Marie Larsson, Juan Armando Mejía, Richard J. Edwards, Jan Malm, Francis Loth, A. Rigamonti, Joel Huovinen, Ikuko Ogino, Antti J. Luikku, V. Eslami, Chihiro Akiba, Wendy C. Ziai, S. Yamada, Rodolfo Casimiro Reis, W. B. Dobyns, M. C. Matiz, Anna Sutela, Katarina Laurell, J. S. Davidson, Montserrat Guerra, Lauriane Jugé, Abhay Moghekar, A. S. Rao, Ritva Vanninen, K. Sandhu, Kostas N. Fountas, Hajime Arai, G. Clemens, D. Riveros, Dan Doherty, J. Wemmer, Richard Holubkov, S. Vakili, Risto P. Roine, Madoka Nakajima, T. L. Wenger, Saman Nekoovaght-Tak, Karl Bechter, Antti Junkkari, Antonio J. Jiménez, Nichol McBee, Catherine McMahon, D. da Vigua, L. Domínguez, Tuomas Rauramaa, M. J. Fritsch, Jaana Rummukainen, N. Badran, M. Maghaslah, Hilkka Soininen, Alfredo Quiñones-Hinojosa, Effie Z. Kapsalaki, Lewis Thorne, Université Catholique de Louvain = Catholic University of Louvain (UCL), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Inönü University, Silicon Nanoelectronics Photonics and Structures (SiNaps), PHotonique, ELectronique et Ingénierie QuantiqueS (PHELIQS), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE), Université de Picardie Jules Verne (UPJV), and CHU Amiens-Picardie

Subjects
Pediatrics, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], 010401 analytical chemistry, MEDLINE, General Medicine, medicine.disease, 01 natural sciences, Meeting Abstracts, lcsh:RC346-429, 0104 chemical sciences, Hydrocephalus, Cellular and Molecular Neuroscience, Text mining, Developmental Neuroscience, Neurology, Medicine, business, lcsh:Neurology. Diseases of the nervous system, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017
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