1. Studies on the dependence of central analgesics
- Author
-
Ichiro Yano
- Subjects
Pharmacology ,medicine.medical_specialty ,Adrenal cortex ,Chemistry ,Codeine ,Mitochondrion ,Matrix (biology) ,Normal state ,Membrane ,medicine.anatomical_structure ,Endocrinology ,Zona fasciculata ,Internal medicine ,Levallorphan ,medicine ,medicine.drug - Abstract
Influences of codeine on the fine structure of zona fasciculata of rat adrenal cortex electron microscopically were studied. The results obtained are as follows. Administering codeine at a dosage of 40mg/kg to normal rats, the honeycombed structures of inner membranes of mitochondria in adrenocortical cells gradually disappeared and the matrix of mitochondria became to less dense. While the deformed structures above-mentioned gradually diminished during the chronic administration of the drug. However, the deformation of inner membranes in mitochondria were produced again in tolerant rats after withdrawal of codeine or treatment of levallorphan, but after the reinjection of codeine, the changes disappeared to the normal state.
- Published
- 1971
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