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Roasted carob powder is produced from the pulp of carob fruit (Ceratonia siliqua L.). In this study, the roasting process was optimized using a central composite design of the response surface methodology in order to maximize the product quality and minimize processing temperature (100–160 °C) and time (5–60 min). Analysis of variance qualified the effect of roasting with different types of models: first, linear models for dry matter, glucose, and ABTS scavenging activity; then, correlative models for proteins, total dietary fibers (TDF), and polyphenols; and last, quadratic models for total flavonoids, flavonols, and DPPH scavenging activity (all significant at p < 0.05). The process increased the antioxidant activity, TDF, and total polyphenol contents, while the concentration of the other components decreased. The optimal conditions for carob roasting were 100 °C for 37.32 min. [ABSTRACT FROM AUTHOR]