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Start Over Author "Kelkel, Mareike" Journal food & chemical toxicology
1 results on '"Kelkel, Mareike"'

1. Synthetic polysulfane derivatives induce cell cycle arrest and apoptotic cell death in human hematopoietic cancer cells.

Author

Czepukojc, Brigitte, Baltes, Anne-Kathrin, Cerella, Claudia, Kelkel, Mareike, Viswanathan, Uma M., Salm, Franz, Burkholz, Torsten, Schneider, Carolin, Dicato, Mario, Montenarh, Mathias, Jacob, Claus, and Diederich, Marc

Subjects
*POLYSULFANES, *CELL cycle, *APOPTOSIS, *CANCER cells, *BENZYL compounds, *TOXICOLOGICAL chemistry
Abstract

Highlights: [•] Novel, garlic-derived, diallyltri- and tetrasulfide derivatives. [•] Benzyl derivative is most active and stable, with improved stability/solubility. [•] Compounds target tubulin, trigger G2/M arrest, followed by intrinsic apoptosis. [•] Good differential toxicity. [Copyright &y& Elsevier]

Published
2014
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