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Your search keyword '"BAJPAI, VIVEK K."' showing total 7 results
Start Over Author "BAJPAI, VIVEK K." Journal food chemistry
7 results on '"BAJPAI, VIVEK K."'

7. (-)-Tetrahydroberberrubine∙acetate accelerates antioxidant potential and inhibits food associated Bacillus cereus in rice.

Author

Bajpai VK, Park I, Khan I, Alshammari FH, Kumar P, Chen L, Na M, Huh YS, Han YK, and Shukla S

Subjects
Alkaloids chemistry, Animals, Anti-Infective Agents chemistry, Antioxidants pharmacology, Bacillus cereus physiology, Bacillus cereus radiation effects, Berberine chemistry, Berberine pharmacology, Biofilms radiation effects, Cell Survival drug effects, Food Microbiology, Mice, NIH 3T3 Cells, Reactive Oxygen Species metabolism, Superoxide Dismutase-1 metabolism, Ultraviolet Rays, Anti-Infective Agents pharmacology, Antioxidants metabolism, Berberine analogs & derivatives, Biofilms drug effects, Oryza microbiology
Abstract

A protoberberine alkaloid, (-)-tetrahydroberberrubine∙acetate (THBA) was assessed for its antioxidant potential and ability to inhibit the growth of a food hazard bacterium Bacillus cereus in vitro and in situ. THBA displayed significant and dose-dependent cellular antioxidant potential against hydrogen peroxide-induced oxidative stress in NIH 3T3 fibroblast cells and decreased the ROS levels as well as increased the expression levels of SOD1 and SOD2 enzymes. The inhibitory spectrum of THBA confirmed its mechanistic role in the disruption of the membrane integrity of B. cereus as evidenced by the results of time-inactivation, cell membrane integrity, NPN membrane uptake, membrane potential, and electron microscopy analyses. Moreover, THBA inhibited biofilm formation by B. cereus and disrupted pre-established biofilms on a glass surface. Furthermore, THBA was also able to inhibit B. cereus in raw rice with a significant amount of reduction in CFU counts, suggesting its potential role as a natural antioxidant and antimicrobial agent., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Published
2021
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