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In recent years, the idea of medicine and food homology (MFH), which highlights the intimate relationship between food and medicine, has gained international recognition. Specifically, MFH substances have the ability to serve as both food and medicine. Many foods have been reported to have good nutritional and medical values, not only for satiety but also for nourishing the body and treating diseases pharmacologically. As modern scientific research has progressed, the concept of MFH has been emphasized and developed in a way that has never been seen before. Therefore, in this paper, we reviewed the development history of MFH substances, summarized some typical bioactive ingredients, and recognized pharmacological effects. In addition, we further discussed the application of MFH substances in the food field, with the goal of providing ideas and references for the research and development of MFH in the food industry as well as the progress of related industries. [Display omitted] • Development history of medicine and food homology (MFH) substances were reviewed. • Main bioactive ingredients and pharmacological effects of 108 MFH substances were summarized. • Current and potential applications of MFH substances in food fields were proposed. • Prospects and challenges of MFH substances were discussed. [ABSTRACT FROM AUTHOR]

Tryptamine is a biogenic amine that affects organoleptic quality through the generation of off-odours in foods. Herein, imine-based covalent organic frameworks (COFs) were synthesized via Schiff base reactions and postmodified with click chemistry to generate azide-functionalized COFs with tunable azide units on the walls. The combination of molecular imprinting with COFs enabled the specific recognition of the targets. The resulting optosensing system (azide-functionalized COFs@MIPs) was used as a sample-to-answer analyser for detecting tryptamine (detection time within 10 min). A linear relationship was observed for the fluorescence response to tryptamine concentrations in the range of 3–120 μg L−1, with a limit of detection of 1.74 μg L−1. The recoveries for spiked samples were satisfactory, with relative standard deviations <9.90%. The optosensing system is a potential tool for the quantitative detection of tryptamine in meat products because of its lower cost, shorter processing time, and simpler processing steps compared to conventional chromatographic techniques. [Display omitted] • Synthesize of imine-based azide-functionalized covalent organic frameworks • Azide-functionalized COFs have good chemical and thermal stability. • Azide-functionalized COFs@MIPs have excellent fluorescence response for tryptamine. • Azide-functionalized COFs@MIPs showed good sensitivity and specificity for tryptamine. • High efficiency, separation effect, radiation stability, and reproducibility [ABSTRACT FROM AUTHOR]