1. Keto analogues and amino acids supplementation induces a decrease of white blood cell counts and a reduction of muscle damage during intense exercise under thermoneutral conditions
- Author
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A. Bassini, Eduardo Seixas Prado, L. C. Cameron, Rafaela Carvalho Pereira Lima, D. S. A. Rodrigues, T. C. L. França, Adriana Ximenes-da-Silva, Saulo Rodrigo Alves e Silva Camerino, and M. G. S. Gouveia
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Hot Temperature ,Lymphocytosis ,medicine.medical_treatment ,Lymphocyte ,03 medical and health sciences ,chemistry.chemical_compound ,Leukocyte Count ,0302 clinical medicine ,White blood cell ,Internal medicine ,Lactate dehydrogenase ,medicine ,Leukocytes ,Humans ,Amino Acids ,Muscle, Skeletal ,Creatine Kinase ,chemistry.chemical_classification ,biology ,L-Lactate Dehydrogenase ,Resistance Training ,030229 sport sciences ,General Medicine ,Eosinophil ,Amino acid ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Athletes ,Immunology ,Dietary Supplements ,biology.protein ,Creatine kinase ,medicine.symptom ,Food Science ,Ketogenic diet - Abstract
This study evaluated the acute effect of keto analogue and amino acid (AA-KAAA) supplementation on both white blood cell counts and the established biomarkers of muscle damage during exercise under thermoneutral conditions. Sixteen male cyclists received a ketogenic diet for two days and were divided into two equal groups: a group taking AA-KAAA (KA) or a control group (PL). The athletes performed a two hour cycling session followed by a maximum incremental test until voluntary exhaustion (VExh). Blood samples were obtained at rest and during exercise for further hematological and biochemical analyses. Exercise-induced ammonemia increased in the PL group at VExh (75%) but remained unchanged in the KA group. Both groups exhibited a significant increase in leukocyte and neutrophil counts of ∼85% (∼13 × 109 L-1), but the shape of the lymphocytes and the eosinophil counts suggest that AA-KAAA supplementation helps prevent lymphocytosis. AA-KAAA supplementation induced a decrease in creatine kinase and aspartate aminotransferase levels at VExh while showing a significant decrease in lactate dehydrogenase at 120 min. We found that AA-KAAA supplementation decreases both the lymphocyte count response in blood and the established biomarkers of muscle damage after intense exercise under a low heat stress environment.
- Published
- 2017