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Your search keyword '"Vindenes, Vigdis"' showing total 21 results
Start Over Author "Vindenes, Vigdis" Journal forensic science international
21 results on '"Vindenes, Vigdis"'

4. Corrigendum to “Differences in combinations and concentrations of drugs of abuse in fatal intoxication and driving under the influence cases” [Forensic Sci. Int. 281 (2017) 127–133]

Author

Edvardsen, Hilde Erøy, primary, Tverborgvik, Torill, additional, Frost, Joachim, additional, Rogde, Sidsel, additional, Morild, Inge, additional, Waal, Helge, additional, Clausen, Thomas, additional, Slørdal, Lars, additional, and Vindenes, Vigdis, additional

Published
2018
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20. Long-term stability of morphine, codeine, and 6-acetylmorphine in real-life whole blood samples, stored at -20 °C.

Author

Høiseth, Gudrun, Fjeld, Bente, Larsen Burns, Margrete, Helge Strand, Dag, and Vindenes, Vigdis

Subjects
*MORPHINE, *CODEINE, *URINALYSIS, *DRUG stability, *FORENSIC toxicology, *BLOOD testing
Abstract

Purpose: Stability of drugs during storage is important in forensic toxicology. For the analytes detected after intake of heroin (6-acetylmorphine (6-AM), morphine and codeine), long-time stability in real life whole blood samples are studied in only a small number of cases. Methods: Whole blood post mortem (n = 37) and whole blood samples from living persons (n = 22) containing morphine and codeine as well as 6-AM in blood or urine were selected. All cases represented intake of heroin. All samples contained fluoride and were initially analysed and stored in normal conditions (-20 °C) for 4-9 years. All samples were then reanalysed using the same analytical methods and the results were compared. Results: For samples from living persons, the median change in concentration was -3.7% for morphine and -5.3% for codeine. For post mortem samples, the median change in concentration was -12% for morphine and -11% for codeine. Both for samples from living persons and post mortem samples, the decrease in the concentrations from the original analysis to reanalysis were statistically significant for morphine and codeine. Regarding 6-AM, all living samples were negative at reanalysis. For post mortem samples, four cases still tested positive for 6-AM at reanalysis with a median change in the concentrations of -81%. There was no significant change in the morphine to codeine concentration ratios neither for living nor post mortem samples. Conclusion: This study showed that in real life whole blood samples, the concentrations of morphine and codeine are relatively stable during long-term storage at -20 °C. 6-AM on the other hand, shows a considerable decrease in concentrations that is important to consider when interpreting results from reanalyses of forensic cases. [ABSTRACT FROM AUTHOR]

Published
2014
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21. Long-term stability of GHB in post-mortem samples and samples from living persons, stored at -20°C, using fluoride preservatives.

Author

Fjeld B, Burns ML, Karinen R, Larssen B, Smith-Kielland A, and Vindenes V

Subjects
Fixatives, Fluorides, Humans, Potassium Compounds, Sodium Fluoride, Time Factors, Cryopreservation, Sodium Oxybate blood, Specimen Handling
Abstract

Purpose: Reanalyses are frequently requested in forensic toxicology, and knowledge of the stability of drugs in biological samples is of major importance for the interpretation of the toxicological findings. Currently, the literature on stability of gammahydroxybutyrate (GHB) in blood samples from living subjects and in post-mortem blood is limited. The purpose of this study was to evaluate the long-term stability of GHB in both blood samples from persons suspected of drug use and post-mortem blood samples., Methods: A total of 59 reanalyses were performed in whole blood samples, 27 samples from living subjects and 32 samples taken at autopsies. The samples were stored in the freezer between 0.4 and 7.2 years at -20°C in vials containing preservatives. Analyses were performed by GC-FID, and cut-off level was 10.3 mg/L. The concentrations in 22 of the samples were below cut-off., Results: The mean change in concentration between initial analysis and reanalysis was -0.8% for the positive samples from living persons and -7.1% for the positive post-mortem samples. Changes ranged from -32.4% to 21.0% for samples from living and from -30.4% to 34.4% for post-mortem samples. All negative samples were still negative at the time of reanalysis., Conclusion: Reanalysis of these forensic whole blood samples stored several years at -20°C with fluoride preservation did not exhibit changes in GHB concentrations of practical significance for the interpretation of toxicological findings., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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