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In a controlled open study 18 patients were treated with high doses of haloperidol (Haldol-Janssen) from 50 to 100 mg daily and 15 patients with a combined therapy of 10 mg haloperidol and 150 to 300 mg levomepromazin (Neurocil). The high-dosed sample a significantly rapid decrease of the productive symptoms and improvement of the general condition were found. The medians of the rating scales and self-rating scales showed similar courses. Within the high-dosage group especially after the beginning of therapy, there was an unexpected significant increase in extrapyramidal signs (dyskinesias), which did not appear any more after starting with an initial dose of at least 50 mg Haldol-Janssen. Other side effects could not be found, the tolerance was good.

The specific use of psychotropic agents in myocardial infarction has become possible due to interdisciplinary cooperation. Especially the differentiated therapeutic application of benzodiazepine derivatives will take into better account the different psychopathologic states in the various phases. The medicamentous facilities are extended by using the central and peripheral effects of the beta-blockers. After a myocardial infarction there are various somatic and mental symptoms. This requires precise medical and psychological management with reference to a diagnostic and combined-therapeutic schedule of treatment. An intensive co-operation with all medical departments is a conditio sine qua non.