Jonas Laget, Claire Vigor, Agathe Nouvel, Amandine Rocher, Jérémy Leroy, Laura Jeanson, Guillaume Reversat, Camille Oger, Jean-Marie Galano, Thierry Durand, Sylvie Péraldi-Roux, Jacqueline Azay-Milhau, and Anne-Dominique Lajoix
During early stages of type 2 diabetes, named prediabetes, pancreatic β-cells compensate for insulin resistance through increased insulin secretion in order to maintain normoglycemia. Obesity leads to the development of ectopic fat deposits, among which peri-pancreatic white adipose tissue (pWAT) can communicate with β-cells through soluble mediators. Thus we investigated whether pWAT produced oxygenated lipids, namely isoprostanes and neuroprostanes and whether they can influence β-cell function in obesity. In the Zucker fa/fa rat model, pWAT and epididymal white adipose tissue (eWAT) displayed different inflammatory profiles. In obese rats, pWAT, but not eWAT, released less amounts of 5-F