1. Genome-wide DNA methylation changes upon DOT1L inhibition in hormone-responsive breast cancer cells.
- Author
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Giurato, Giorgio, Terenzi, Ilaria, Chiuso, Francesco, Salvati, Annamaria, Rizzo, Francesca, Tarallo, Roberta, Weisz, Alessandro, and Nassa, Giovanni
- Subjects
DNA methylation ,CANCER cell growth ,ESTROGEN ,DNA methyltransferases ,BREAST cancer ,CANCER cells ,DEVELOPMENTAL biology - Abstract
This article discusses a study on DNA methylation changes in hormone-responsive breast cancer cells. The researchers inhibited two proteins, ERα and DOT1L, and analyzed the resulting DNA methylation patterns using bioinformatics and functional annotation analyses. They found that the differentially methylated CpGs were mainly located in gene promoters and enhancers, and these changes were associated with estrogen response gene pathways. The study provides valuable data for future research on the role of DNA methylation in breast cancer. The article also includes information about funding sources, conflicts of interest, and references to other relevant articles. [Extracted from the article]
- Published
- 2023
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