1. Potential Impact of Rapid Multiplex PCR on Antimicrobial Therapy Guidance for Ventilated Hospital-Acquired Pneumonia in Critically Ill Patients, A Prospective Observational Clinical and Economic Study
- Author
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Florian Guillotin, Cécile Poulain, Benjamin Gaborit, Marwan Bouras, Raphaël Cinotti, Karim Lakhal, Mickael Vourc’h, Bertrand Rozec, Karim Asehnoune, Marie-Anne Vibet, Valéry-Pierre Riche, Sophie-Anne Gibaud, Lise Crémet, and Antoine Roquilly
- Subjects
pneumonia ,biomolecular diagnosis ,empiric treatment ,intensive care unit ,hospital-acquired pneumonia ,Microbiology ,QR1-502 - Abstract
ObjectivesTo investigate the potential impact of the syndromic multiplex FilmArray® Pneumonia plus Panel (FAPP) on the antimicrobial treatment guidance of patients with ventilated hospital-acquired pneumonia (VHAP).MethodsRespiratory fluids from 100 adult patients with VHAP, receiving invasive mechanical ventilation in three intensive care units from one French university hospital, were tested prospectively using FAPP. Conventional cultures were performed in parallel as routine practice. Clinicians were left blinded to the FAPP results. Antimicrobial therapies based on FAPP results were simulated by independent blinded experts according to a predefined algorithm and compared to 1) those prescribed in practice according to local guidelines (real-life), and 2) those that complied with the international ERS/ESICM/ESCMID/ALAT recommendations. The primary endpoint was the number of days of broad-spectrum antimicrobial therapy. Secondary endpoints were the rates of microbiological treatment failure and cost-effectiveness ratio.ResultsThe predicted median duration of broad-spectrum antibiotics was 0 [0-1.25] day in the FAPP-based simulation, versus 2 [0-6] days in real-life (p
- Published
- 2022
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