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Your search keyword '"Motsinger-Reif, Alison A"' showing total 8 results
Start Over Author "Motsinger-Reif, Alison A" Journal frontiers in genetics
8 results on '"Motsinger-Reif, Alison A"'

1. Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program

Author

Armstrong, Nicole D., primary, Srinivasasainagendra, Vinodh, additional, Ammous, Farah, additional, Assimes, Themistocles L., additional, Beitelshees, Amber L., additional, Brody, Jennifer, additional, Cade, Brian E., additional, Ida Chen, Yii-Der, additional, Chen, Han, additional, de Vries, Paul S., additional, Floyd, James S., additional, Franceschini, Nora, additional, Guo, Xiuqing, additional, Hellwege, Jacklyn N., additional, House, John S., additional, Hwu, Chii-Min, additional, Kardia, Sharon L. R., additional, Lange, Ethan M., additional, Lange, Leslie A., additional, McDonough, Caitrin W., additional, Montasser, May E., additional, O’Connell, Jeffrey R., additional, Shuey, Megan M., additional, Sun, Xiao, additional, Tanner, Rikki M., additional, Wang, Zhe, additional, Zhao, Wei, additional, Carson, April P., additional, Edwards, Todd L., additional, Kelly, Tanika N., additional, Kenny, Eimear E., additional, Kooperberg, Charles, additional, Loos, Ruth J. F., additional, Morrison, Alanna C., additional, Motsinger-Reif, Alison, additional, Psaty, Bruce M., additional, Rao, Dabeeru C., additional, Redline, Susan, additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Smith, Jennifer A., additional, Smith, Albert V., additional, Irvin, Marguerite R., additional, and Arnett, Donna K., additional

Published
2023
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2. Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma

Author

Lee, Eunice Y., primary, Choi, Wonson, additional, Burkholder, Adam B., additional, Perera, Lalith, additional, Mack, Jasmine A., additional, Miller, Frederick W., additional, Fessler, Michael B., additional, Cook, Donald N., additional, Karmaus, Peer W. F., additional, Nakano, Hideki, additional, Garantziotis, Stavros, additional, Madenspacher, Jennifer H., additional, House, John S., additional, Akhtari, Farida S., additional, Schmitt, Charles S., additional, Fargo, David C., additional, Hall, Janet E., additional, and Motsinger-Reif, Alison A., additional

Published
2023
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8. A comparison of association methods for cytotoxicity mapping in pharmacogenomics.

Author

Brown C, Havener TM, Everitt L, McLeod H, and Motsinger-Reif AA

Abstract

Cytotoxicity assays of immortalized lymphoblastoid cell lines (LCLs) represent a promising new in vitro approach in pharmacogenomics research. However, previous studies employing LCLs in gene mapping have used simple association methods, which may not adequately capture the true differences in non-linear response profiles between genotypes. Two common approaches summarize each dose-response curve with either the IC50 or the slope parameter estimates from a hill slope fit and treat these estimates as the response in a linear model. The current study investigates these two methods, as well as four novel methods, and compares their power to detect differences between the response profiles of genotypes under a variety of different alternatives. The four novel methods include two methods that summarize each dose-response by its area under the curve, one method based off of an analysis of variance (ANOVA) design, and one method that compares hill slope fits for all individuals of each genotype. The power of each method was found to depend not only on the choice of alternative, but also on the choice for the set of dosages used in cytotoxicity measurements. The ANOVA-based method was found to be the most robust across alternatives and dosage sets for power in detecting differences between genotypes.

Published
2011
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