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Your search keyword '"Klatzmann, David"' showing total 12 results
Start Over Author "Klatzmann, David" Journal frontiers in immunology
12 results on '"Klatzmann, David"'

1. Interleukin-1 regulates follicular T cells during the germinal center reaction

Author

Belbezier, Aude, primary, Engeroff, Paul, additional, Fourcade, Gwladys, additional, Vantomme, Hélène, additional, Vaineau, Romain, additional, Gouritin, Bruno, additional, Bellier, Bertrand, additional, Brocheriou, Isabelle, additional, Tchitchek, Nicolas, additional, Graff-Dubois, Stephanie, additional, and Klatzmann, David, additional

Published
2024
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6. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

Author

Fuchs, Anke, primary, Gliwiński, Mateusz, additional, Grageda, Nathali, additional, Spiering, Rachel, additional, Abbas, Abul K., additional, Appel, Silke, additional, Bacchetta, Rosa, additional, Battaglia, Manuela, additional, Berglund, David, additional, Blazar, Bruce, additional, Bluestone, Jeffrey A., additional, Bornhäuser, Martin, additional, ten Brinke, Anja, additional, Brusko, Todd M., additional, Cools, Nathalie, additional, Cuturi, Maria Cristina, additional, Geissler, Edward, additional, Giannoukakis, Nick, additional, Gołab, Karolina, additional, Hafler, David A., additional, van Ham, S. Marieke, additional, Hester, Joanna, additional, Hippen, Keli, additional, Di Ianni, Mauro, additional, Ilic, Natasa, additional, Isaacs, John, additional, Issa, Fadi, additional, Iwaszkiewicz-Grześ, Dorota, additional, Jaeckel, Elmar, additional, Joosten, Irma, additional, Klatzmann, David, additional, Koenen, Hans, additional, van Kooten, Cees, additional, Korsgren, Olle, additional, Kretschmer, Karsten, additional, Levings, Megan, additional, Marek-Trzonkowska, Natalia Maria, additional, Martinez-Llordella, Marc, additional, Miljkovic, Djordje, additional, Mills, Kingston H.G., additional, Miranda, Joana P., additional, Piccirillo, Ciriaco A., additional, Putnam, Amy L., additional, Ritter, Thomas, additional, Roncarolo, Maria Grazia, additional, Sakaguchi, Shimon, additional, Sánchez-Ramón, Silvia, additional, Sawitzki, Birgit, additional, Sofronic-Milosavljevic, Ljiljana, additional, Sykes, Megan, additional, Tang, Qizhi, additional, Vives-Pi, Marta, additional, Waldmann, Herman, additional, Witkowski, Piotr, additional, Wood, Kathryn J., additional, Gregori, Silvia, additional, Hilkens, Catharien M. U., additional, Lombardi, Giovanna, additional, Lord, Phillip, additional, Martinez-Caceres, Eva M., additional, and Trzonkowski, Piotr, additional

Published
2018
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7. Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data

Author

Breden, Felix, primary, Luning Prak, Eline T., additional, Peters, Bjoern, additional, Rubelt, Florian, additional, Schramm, Chaim A., additional, Busse, Christian E., additional, Vander Heiden, Jason A., additional, Christley, Scott, additional, Bukhari, Syed Ahmad Chan, additional, Thorogood, Adrian, additional, Matsen IV, Frederick A., additional, Wine, Yariv, additional, Laserson, Uri, additional, Klatzmann, David, additional, Douek, Daniel C., additional, Lefranc, Marie-Paule, additional, Collins, Andrew M., additional, Bubela, Tania, additional, Kleinstein, Steven H., additional, Watson, Corey T., additional, Cowell, Lindsay G., additional, Scott, Jamie K., additional, and Kepler, Thomas B., additional

Published
2017
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11. Human and mouse CD8+CD25+FOXP3+ regulatory T cells at steady state and during interleukin-2 therapy.

Author

Churlaud, Guillaume, Pitoiset, Fabien, Jebbawi, Fadi, Lorenzon, Roberta, Bellier, Bertrand, Rosenzwajg, Michelle, and Klatzmann, David

Subjects
HUMAN T cells, INTERLEUKIN-2, CD8 antigen, CD25 antigen, AUTOIMMUNE diseases, LABORATORY mice, LYMPH nodes
Abstract

In addition to CD4 + regulatoryT cells (Tregs), CD8 + suppressorT cells are emerging as an important subset of regulatory T cells. Diverse populations of CD8CT cells with suppressive activities have been described. Among them, a small population of CD8 +CD25 +FOxP3 + T cells is found both in mice and humans. In contrast to thymic-derived CD4 +CD25 +FOXP3 + Tregs, their origin and their role in the pathophysiology of autoimmune diseases (AIDs) are less understood.We report here the number, phenotype, and function of CD8 + Tregs cells in mice and humans, at the steady state and in response to low-dose interleukin-2 (IL-2). CD8 + Tregs represent approximately 0.4 and 0.1% of peripheral blood T cells in healthy humans and mice, respectively. In mice, their frequencies are quite similar in lymph nodes (LNs) and the spleen, but two to threefold higher in Peyer patches and mesenteric LNs. CD8 + Tregs express low levels of CD127. CD8 + Tregs express more activation or proliferation markers such as CTLA-4, ICOS, and Ki-67 than other CD8+ T cells. In vitro, they suppress effector T cell proliferation as well as or even better than CD4 + Tregs. Owing to constitutive expression of CD25, CD8 + Tregs are 20- to 40-fold more sensitive to in vitro IL-2 stimulation than CD8 + effector T cells, but 2-4 times less than CD4 + Tregs. Nevertheless, low-dose IL-2 dramatically expands and activates CD8 + Tregs even more than CD4 + Tregs, in mice and humans. Further studies are warranted to fully appreciate the clinical relevance of CD8 + Tregs in AIDs and the efficacy of IL-2 treatment. [ABSTRACT FROM AUTHOR]

Published
2015
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12. Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data

Author

Felix Breden, Eline T. Luning Prak, Bjoern Peters, Florian Rubelt, Chaim A. Schramm, Christian E. Busse, Jason A. Vander Heiden, Scott Christley, Syed Ahmad Chan Bukhari, Adrian Thorogood, Frederick A. Matsen IV, Yariv Wine, Uri Laserson, David Klatzmann, Daniel C. Douek, Marie-Paule Lefranc, Andrew M. Collins, Tania Bubela, Steven H. Kleinstein, Corey T. Watson, Lindsay G. Cowell, Jamie K. Scott, Thomas B. Kepler, KLATZMANN, DAVID, Simon Fraser University (SFU.ca), University of Pennsylvania, La Jolla Institute for Immunology [La Jolla, CA, États-Unis], Stanford University School of Medicine [CA, USA], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Neuroscience, Yale University School of Medicine, Yale School of Medicine [New Haven, Connecticut] (YSM), University of Texas Southwestern Medical Center [Dallas], McGill University = Université McGill [Montréal, Canada], Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Tel Aviv University (TAU), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] (I3), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), International ImMunoGeneTics Information System (IMGT), Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Institut de génétique humaine (IGH), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), University of New South Wales [Sydney] (UNSW), University of Louisville, Boston University School of Medicine (BUSM), and Boston University [Boston] (BU)

Subjects
lcsh:Immunologic diseases. Allergy, 0301 basic medicine, B-cell receptors, data sharing, Immunology, immunoglobulins, community standards, Immune receptor, Reuse, Biology, USable, Bioinformatics, 03 medical and health sciences, 0302 clinical medicine, antibodies, Immunology and Allergy, Community standards, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Repertoire, high-throughput sequencing, [SDV.ETH] Life Sciences [q-bio]/Ethics, Acquired immune system, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Data science, [SDV.ETH]Life Sciences [q-bio]/Ethics, 3. Good health, immunogenetics, Data sharing, T-cell receptors, 030104 developmental biology, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, 030220 oncology & carcinogenesis, Perspective, lcsh:RC581-607
Abstract

International audience; High-throughput sequencing (HTS) of immunoglobulin (B-cell receptor, antibody) and T-cell receptor repertoires has increased dramatically since the technique was introduced in 2009 (1–3). This experimental approach explores the maturation of the adaptive immune system and its response to antigens, pathogens, and disease conditions in exquisite detail. It holds significant promise for diagnostic and therapy-guiding applications. New technology often spreads rapidly, sometimes more rapidly than the understanding of how to make the products of that technology reliable, reproducible, or usable by others. As complex technologies have developed, scientific communities have come together to adopt common standards, protocols, and policies for generating and sharing data sets, such as the MIAME protocols developed for microarray experiments. The Adaptive Immune Receptor Repertoire (AIRR) Community formed in 2015 to address similar issues for HTS data of immune repertoires. The purpose of this perspective is to provide an overview of the AIRR Community’s founding principles and present the progress that the AIRR Community has made in developing standards of practice and data sharing protocols. Finally, and most important, we invite all interested parties to join this effort to facilitate sharing and use of these powerful data sets (join@airr-community.org).

Published
2017
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