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Your search keyword '"Monteiro, Wuelton"' showing total 11 results
Start Over Author "Monteiro, Wuelton" Journal frontiers in immunology
11 results on '"Monteiro, Wuelton"'

1. Temporal patterns of cytokine and injury biomarkers in hospitalized COVID-19 patients treated with methylprednisolone

Author

Mwangi, Victor Irungu, primary, Netto, Rebeca Linhares Abreu, additional, de Morais, Carlos Eduardo Padron, additional, Silva, Arineia Soares, additional, Silva, Bernardo Maia, additional, Lima, Amanda Barros, additional, Neves, Juliana Costa Ferreira, additional, Borba, Mayla Gabriela Silva, additional, Val, Fernando Fonseca de Almeida e, additional, de Almeida, Anne Cristine Gomes, additional, Costa, Allyson Guimarães, additional, Sampaio, Vanderson de Souza, additional, Gardinassi, Luiz Gustavo, additional, de Lacerda, Marcus Vinicius Guimarães, additional, Monteiro, Wuelton Marcelo, additional, and de Melo, Gisely Cardoso, additional

Published
2023
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2. Temporal patterns of cytokine and injury biomarkers in hospitalized COVID-19 patients treated with methylprednisolone.

Author

Irungu Mwangi, Victor, Linhares Abreu Netto, Rebeca, Padron de Morais, Carlos Eduardo, Soares Silva, Arineia, Silva, Bernardo Maia, Barros Lima, Amanda, Costa Ferreira Neves, Juliana, Silva Borba, Mayla Gabriela, Fonseca de Almeida e. Val, Fernando, Gomes de Almeida, Anne Cristine, Guimarães Costa, Allyson, de Souza Sampaio, Vanderson, Gardinassi, Luiz Gustavo, Guimarães de Lacerda, Marcus Vinicius, Monteiro, Wuelton Marcelo, and Cardoso de Melo, Gisely

Subjects
COVID-19, TROPONIN I, SARS-CoV-2, METHYLPREDNISOLONE, CYTOKINES, CORONAVIRUS diseases
Abstract

Background: The novel coronavirus disease 2019 (COVID-19) presents with complex pathophysiological effects in various organ systems. Following the COVID-19, there are shifts in biomarker and cytokine equilibrium associated with altered physiological processes arising from viral damage or aggressive immunological response. We hypothesized that high daily dose methylprednisolone improved the injury biomarkers and serum cytokine profiles in COVID-19 patients. Methods: Injury biomarker and cytokine analysis was performed on 50 SARS-Cov-2 negative controls and 101 hospitalized severe COVID-19 patients: 49 methylprednisolone-treated (MP group) and 52 placebo-treated serum samples. Samples from the treated groups collected on days D1 (pre-treatment) all the groups, D7 (2 days after ending therapy) and D14 were analyzed. Luminex assay quantified the biomarkers HMGB1, FABP3, myoglobin, troponin I and NTproBNP. Immune mediators (CXCL8, CCL2, CXCL9, CXCL10, TNF, IFN-γ, IL-17A, IL-12p70, IL-10, IL-6, IL-4, IL-2, and IL-1β) were quantified using cytometric bead array. Results: At pretreatment, the two treatment groups were comparable demographically. At pre-treatment (D1), injury biomarkers (HMGB1, TnI, myoglobin and FABP3) were distinctly elevated. At D7, HMGB1 was significantly higher in the MP group (p=0.0448) compared to the placebo group, while HMGB1 in the placebo group diminished significantly by D14 (p=0.0115). Compared to healthy control samples, several immune mediators (IL-17A, IL-6, IL-10, MIG, MCP-1, and IP-10) were considerably elevated at baseline (all p≤0.05). At D7, MIG and IP-10 of the MP-group were significantly lower than in the placebo-group (p=0.0431, p=0.0069, respectively). Longitudinally, IL-2 (MPgroup) and IL-17A (placebo-group) had increased significantly by D14. In placebo group, IL-2 and IL-17A continuously increased, as IL-12p70, IL-10 and IP-10 steadily decreased during follow-up. The MP treated group had IL-2, IFN-γ, IL-17A and IL-12p70 progressively increase while IL-1b and IL-10 gradually decreased towards D14. Moderate to strong positive correlations between chemokines and cytokines were observed on D7 and D14. Conclusion: These findings suggest MP treatment could ameliorate levels of myoglobin and FABP3, but appeared to have no impact on HMGB1, TnI and NTproBNP. In addition, methylprednisolone relieves the COVID-19 induced inflammatory response by diminishing MIG and IP-10 levels. Overall, corticosteroid (methylprednisolone) use in COVID-19 management influences the immunological molecule and injury biomarker profile in COVID-19 patients. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations

Author

Adrião, Asenate A. X., primary, dos Santos, Aline O., additional, de Lima, Emilly J. S. P., additional, Maciel, Jéssica B., additional, Paz, Weider H. P., additional, da Silva, Felipe M. A., additional, Pucca, Manuela B., additional, Moura-da-Silva, Ana M., additional, Monteiro, Wuelton M., additional, Sartim, Marco A., additional, and Koolen, Hector H. F., additional

Published
2022
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5. Bothrops bilineatus: An Arboreal Pitviper in the Amazon and Atlantic Forest

Author

Bernarde, Paulo Sérgio, primary, Pucca, Manuela Berto, additional, Mota-da-Silva, Ageane, additional, da Fonseca, Wirven Lima, additional, de Almeida, Marllus Rafael Negreiros, additional, de Oliveira, Isadora Sousa, additional, Cerni, Felipe Augusto, additional, Gobbi Grazziotin, Felipe, additional, Sartim, Marco A., additional, Sachett, Jacqueline, additional, Wen, Fan Hui, additional, Moura-da-Silva, Ana Maria, additional, and Monteiro, Wuelton M., additional

Published
2021
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7. Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology

Author

Pucca, Manuela B., primary, Bernarde, Paulo Sérgio, additional, Rocha, Anderson Maciel, additional, Viana, Patrik F., additional, Farias, Raimundo Erasmo Souza, additional, Cerni, Felipe A., additional, Oliveira, Isadora S., additional, Ferreira, Isabela G., additional, Sandri, Eliseu A., additional, Sachett, Jacqueline, additional, Wen, Fan Hui, additional, Sampaio, Vanderson, additional, Laustsen, Andreas H., additional, Sartim, Marco A., additional, and Monteiro, Wuelton M., additional

Published
2021
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8. Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIV-Associated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial

Author

Safe, Izabella P., primary, Amaral, Eduardo P., additional, Araújo-Pereira, Mariana, additional, Lacerda, Marcus V. G., additional, Printes, Vitoria S., additional, Souza, Alexandra B., additional, Beraldi-Magalhães, Francisco, additional, Monteiro, Wuelton M., additional, Sampaio, Vanderson S., additional, Barreto-Duarte, Beatriz, additional, Andrade, Alice M. S., additional, Spener-Gomes, Renata, additional, Costa, Allyson Guimarães, additional, Cordeiro-Santos, Marcelo, additional, and Andrade, Bruno B., additional

Published
2021
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9. Correlating Fibrinogen Consumption and Profiles of Inflammatory Molecules in Human Envenomation's by Bothrops atrox in the Brazilian Amazon

Author

Wellmann, Irmgardt Alicia María, primary, Ibiapina, Hiochelson Najibe Santos, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Sartim, Marco Aurélio, additional, Silva, Iran Mendonça, additional, Oliveira, Sâmella Silva, additional, Tarragô, Andréa Monteiro, additional, Moura-da-Silva, Ana Maria, additional, Lacerda, Marcus Vinícius Guimarães, additional, Ferreira, Luiz Carlos de Lima, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2020
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10. Plasma Eicosanoid Profile in Plasmodium vivax Malaria: Clinical Analysis and Impacts of Self-Medication

Author

Abreu-Filho, Péricles Gama, primary, Tarragô, Andrea Monteiro, additional, Costa, Allyson Guimarães, additional, Monteiro, Wuelton Marcelo, additional, Meielles, Alyne Fávero Galvão, additional, Costa, Thainá Cristina Cardoso, additional, Silva, Jéssica Santos, additional, Zambuzi, Fabiana Albani, additional, Gardinassi, Luiz Gustavo, additional, Moraes, Luiz Alberto Beraldo, additional, Lacerda, Marcus Vinícius Guimarães, additional, Sorgi, Carlos Arterio, additional, Faccioli, Lúcia Helena, additional, and Malheiro, Adriana, additional

Published
2019
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11. An Immunological Stairway to Severe Tissue Complication Assembly in Bothrops atrox Snakebites

Author

Ibiapina, Hiochelson Najibe Santos, primary, Costa, Allyson Guimarães, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Silva, Iran Mendonça, additional, Tarragô, Andréa Monteiro, additional, Neves, Juliana Costa Ferreira, additional, Kerr, Marllon Wendell Athaydes, additional, Santana, Monique Freire, additional, Martins-Filho, Olindo Assis, additional, Lacerda, Marcus Vinícius Guimarães, additional, Ferreira, Luiz Carlos Lima, additional, Malheiro, Adriana, additional, and Monteiro, Wuelton Marcelo, additional

Published
2019
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